Structure‐based varieties of polymeric nanocarriers and influences of their physicochemical properties on drug delivery profiles

R De, MK Mahata, KT Kim - Advanced Science, 2022 - Wiley Online Library
Carriers are equally important as drugs. They can substantially improve bioavailability of
cargos and safeguard healthy cells from toxic effects of certain therapeutics. Recently …

Nanogels as novel drug nanocarriers for CNS drug delivery

V Manimaran, RP Nivetha, T Tamilanban… - Frontiers in Molecular …, 2023 - frontiersin.org
Nanogels are highly recognized as adaptable drug delivery systems that significantly
contribute to improving various therapies and diagnostic examinations for different human …

A predictive microfluidic model of human glioblastoma to assess trafficking of blood–brain barrier-penetrant nanoparticles

JP Straehla, C Hajal, HC Safford… - Proceedings of the …, 2022 - National Acad Sciences
The blood–brain barrier represents a significant challenge for the treatment of high-grade
gliomas, and our understanding of drug transport across this critical biointerface remains …

Preparation and use of nanogels as carriers of drugs

C Li, SR Obireddy, WF Lai - Drug delivery, 2021 - Taylor & Francis
Nanogels have high tunability and stability while being able to sense and respond to
external stimuli by showing changes in the gel volume, water content, colloidal stability …

From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer

E Gonzales-Aloy, A Ahmed-Cox, M Tsoli… - Advanced Drug Delivery …, 2023 - Elsevier
Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

Stimuli‐responsive multifunctional nanomedicine for enhanced glioblastoma chemotherapy augments multistage blood‐to‐brain trafficking and tumor targeting

C Martins, M Araújo, A Malfanti, C Pacheco, SJ Smith… - Small, 2023 - Wiley Online Library
Minimal therapeutic advances have been achieved over the past two decades for
glioblastoma (GBM), which remains an unmet clinical need. Here, hypothesis‐driven stimuli …

[HTML][HTML] Access to the CNS: Strategies to overcome the BBB

B Sánchez-Dengra, I González-Álvarez… - International Journal of …, 2023 - Elsevier
The blood–brain barrier (BBB) limits the access of substances to the central nervous system
(CNS) which hinders the treatment of pathologies affecting the brain and the spinal cord …

Nanogels as a versatile drug delivery system for brain cancer

B Stawicki, T Schacher, H Cho - Gels, 2021 - mdpi.com
Chemotherapy and radiation remain as mainstays in the treatment of a variety of cancers
globally, yet some therapies exhibit limited specificity and result in harsh side effects in …

Effects of nanoparticle deformability on multiscale biotransport

HH Gadalla, Z Yuan, Z Chen, F Alsuwayyid… - Advanced Drug Delivery …, 2024 - Elsevier
Deformability is one of the critical attributes of nanoparticle (NP) drug carriers, along with
size, shape, and surface properties. It affects various aspects of NP biotransport, ranging …

Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion

JM Rabanel, M Mirbagheri, M Olszewski, G Xie… - ACS …, 2022 - ACS Publications
Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply
penetrating into dense tissues of the CNS could potentially transform the management of …