Polymeric materials have been extensively explored in the field of nanomedicine; within
them, poly lactic-co-glycolic acid (PLGA) holds a prominent position in micro-and …

At nanoscale, man-made materials may show unique properties that differ from bulk and
dissolved counterparts. The unique properties of engineered nanomaterials not only impart …

Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …

Background A positive surface charge has been largely associated with nanoparticle (NP)
toxicity. However, by screening a carbon NP library in macrophages, we found that a …

Chitosan is one of the most used polysaccharides in the design of drug delivery strategies
for administration of either biomacromolecules or low molecular weight drugs. For these …

Used since ancient times especially for the local treatment of pulmonary diseases, lungs and
airways are a versatile target route for the administration of both local and systemic drugs …

Microscale cell carriers have recently garnered enormous interest in repairing tissue defects
by avoiding substantial open surgeries using implants for tissue regeneration. In this study …

Biodegradable polymeric materials are the most common carriers for use in drug delivery
systems. With this trend, newer drug delivery systems using targeted and controlled release …

Highlights•The Biologically Effective Dose (BED) is the mechanistic entity that actually drives
toxicity.•Mechanisms of nanoparticle (NP) toxicity need to be considered in relation to …

Parkinson's disease (PD) is a debilitating neurodegenerative condition characterized by the
loss of dopaminergic neurons within the substantia nigra. The specific molecular …