Aconitine: A review of its pharmacokinetics, pharmacology, toxicology and detoxification

Y Gao, H Fan, A Nie, K Yang, H Xing, Z Gao… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Aconitine, a C 19-norditerpenoid alkaloid, derives from
many medicinal plants such as Aconitum carmichaelii Debx.(Chinese: 乌头), Aconitum …

Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison

W Zhou, H Liu, LZ Qiu, LX Yue… - Medicinal research …, 2021 - Wiley Online Library
Aconitine (AC) is well‐known as the main toxic ingredient and active compound of Aconitum
species, of which several aconites are essential herbal medicines of Traditional Chinese …

Design, synthesis, and biological evaluation of low-toxic lappaconitine derivatives as potential analgesics

Y Li, Y Shang, X Li, Y Zhang, J Xie, L Chen… - European Journal of …, 2022 - Elsevier
The C 18-diterpenoid alkaloid lappaconitine (LA) is a non-addictive analgesic used in
China. The toxicity (LD 50= 11.7 mg/kg) limits its application. Two series of LA derivatives …

Natural Composition and Biosynthetic Pathways of Alkaloids in Medicinal Dendrobium Species

C Song, J Ma, G Li, H Pan, Y Zhu, Q Jin… - Frontiers in Plant …, 2022 - frontiersin.org
Dendrobium is the second biggest genus in the Orchidaceae family, some of which have
both ornamental and therapeutic values. Alkaloids are a group of active chemicals found in …

Pyrrolidine alkaloids and their promises in pharmacotherapy

MT Islam, MS Mubarak - Advances in Traditional Medicine, 2020 - Springer
This review aimed at summarizing the literature pertaining to the biological activities of
pyrrolidine alkaloids and their derivatives obtained from various sources. For this purpose …

Comprehensive insight into the pharmacology, pharmacokinetics, toxicity, detoxification and extraction of hypaconitine from Aconitum plants

G Xiang, S Guo, J Qin, H Gao, Y Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Hypaconitine (HA), a diterpenoid alkaloid, mainly derived
from Aconitum plants such as Acoitum carmichaeli Debx. And Aconitum nagarum Stapf., has …

Non-alkaloidal constituents from the genus Aconitum: a review

T Yin, H Zhou, L Cai, Z Ding - RSC advances, 2019 - pubs.rsc.org
Species of the genus Aconitum are widely distributed in the north temperate region and
have been used in traditional medicine since antiquity due to their biological activities …

Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish

Q Ye, H Liu, C Fang, Y Liu, X Liu, J Liu… - Drug and Chemical …, 2021 - Taylor & Francis
Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but
exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death …

Discrimination of the Geographical Origin of the Lateral Roots of Aconitum carmichaelii Using the Fingerprint, Multicomponent Quantification, and Chemometric …

LL Miao, QM Zhou, C Peng, CW Meng, XY Wang… - Molecules, 2019 - mdpi.com
Fuzi is a well-known traditional Chinese medicine developed from the lateral roots of
Aconitum carmichaelii Debx. It is rich in alkaloids that display a wide variety of bioactivities …

Benzoylaconine: Potential Therapeutic Agent for Cardiovascular Diseases From Fuzi

C Xu, L Tang, L Hu, Y Huang, J Tang… - Cardiovascular …, 2024 - Wiley Online Library
Modern pharmacological studies have elucidated the presence of aconitine (AC) alkaloids,
polysaccharides, and saponins as the primary bioactive constituents of Fuzi. Among these …