Proteolytic activation of the epithelial Sodium Channel (ENaC): Its mechanisms and implications

M Aufy, AM Hussein, T Stojanovic, CR Studenik… - International Journal of …, 2023 - mdpi.com
Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in
various biological tissues, including the kidney, lung, and colon. They enable the selective …

The significance of Cathepsin B in mediating radiation resistance in colon carcinoma cell line (Caco-2)

RF Abdelaziz, AM Hussein, MH Kotob, C Weiss… - International Journal of …, 2023 - mdpi.com
Cathepsins (Caths) are lysosomal proteases that participate in various physiological and
pathological processes. Accumulating evidence suggests that caths play a multifaceted role …

Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells

RF Abdelaziz, AM Hussein, MH Kotob, C Weiss… - International Journal of …, 2023 - mdpi.com
Cancer is one of the main causes of death globally. Radiotherapy/Radiation therapy (RT) is
one of the most common and effective cancer treatments. RT utilizes high-energy radiation …

Evidence of Guanidines Potential against Leishmania (Viannia) braziliensis: Exploring In Vitro Effectiveness, Toxicities and of Innate Immunity Response Effects

LR Dos Anjos, VMR de Souza, YAA Machado… - Biomolecules, 2023 - mdpi.com
Leishmaniasis is a complex group of infectious and parasitic diseases that afflict many
thousands of individuals across five continents. Leishmaniasis treatment remains a …

Comparative transcriptome analysis to unveil genes affecting the host cuticle destruction in Metarhizium rileyi

L Fan, X Li, H Li, B Li, J Wang, L He, Z Wang, Y Lin - Current Genetics, 2023 - Springer
Insect pathogenic fungi, also known as entomopathogenic fungi, are one of the largest
insect pathogenic microorganism communities, represented by Beauveria spp. and …

Anti-tumor activity of beauvericin: focus on intracellular signaling pathways

R Liu, J Ouyang, L Li - Mycotoxin Research, 2024 - Springer
Beauvericin, a Fusarium mycotoxin commonly found in feeds, particularly cereals worldwide,
exhibits a wide array of biofunction. It exhibits anticancer characteristics in addition to its …

Genotoxicity of beauvericin

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2024 - Wiley Online Library
Abstract The European Commission (EC) asked EFSA to assess the genotoxicity of
beauvericin (BEA). Relevant information, including that which has become available since …

The mode of action of enniatins A and B is mediated by interaction with SOC reservoirs (A) and mitochondrial permeability transition pore (B)

N Pérez-Fuentes, R Alvariño, A Alfonso… - Exposure and …, 2024 - Springer
Abstract Enniatins (ENNs) A and B have long been described as ionophores, but their
mechanism of action remains unclear. In this study, their effects on Ca2+ fluxes and …

Beauvericin Reverses Epithelial-to-Mesenchymal Transition in Triple-Negative Breast Cancer Cells through Regulation of Notch Signaling and Autophagy

A Patra, A Arora, SS Ghosh… - ACS Pharmacology & …, 2024 - ACS Publications
Metastasis stands as a prime contributor to triple-negative breast cancer (TNBC) associated
mortality worldwide, presenting heightened severity and significant challenges due to limited …

Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure

M Aufy, M Abd-Elkareem, M Mustafic… - PloS one, 2024 - journals.plos.org
Introduction The aging process is intricately linked to alterations in cellular and tissue
structures, with the respiratory system being particularly susceptible to age-related changes …