Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …

Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

Neuroinflammation is one of the hallmarks of Parkinson's disease (PD) and may contribute
to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation …

Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …

Progress has been made over the last 10 years in determining the neural mechanisms of
sensitization induced by amphetamine-like psychostimulants, opioids and stressors …

3.3. Electrophysiological basis of tonic firing in thalamic relay neurons 3.4. High frequency
(30-50 Hz) rhythms in thalamic neurons 3.5. Functional consequences of …

Repeated exposure to psychostimulants such as cocaine and amphetamine produces
behavioral sensitization, which is characterized by an augmented locomotor response to a …

1. Intracellular recordings were made from 241 ventral tegmental neurones in slices of rat
midbrain. Seventy‐seven per cent of neurones were hyperpolarized by dopamine (principal …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

The description of new dopamine (DA) receptor subtypes, D1-(D1 and D5) and D2-like
(D2A, D2B, D3, D4), has given an impetus to DA research. While selective agonists and …