Potential Protective Effects of Antioxidants against Cyclophosphamide‐Induced Nephrotoxicity

MA Ayza, KA Zewdie, EF Yigzaw… - International Journal …, 2022 - Wiley Online Library
Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful
drugs with wide arrays of clinical activity. It has been in use for several types of cancer …

Protective effects of antioxidants on cyclophosphamide-induced ovarian toxicity

RS Barberino, RLS Silva… - Biopreservation and …, 2023 - liebertpub.com
The most common limitation of anticancer chemotherapy is the injury to normal cells.
Cyclophosphamide, which is one of the most widely used alkylating agents, can cause …

The effects of selenium in acrylamide-induced nephrotoxicity in rats: roles of oxidative stress, inflammation, apoptosis, and DNA damage

E Sengul, V Gelen, S Yildirim, S Tekin… - Biological trace element …, 2021 - Springer
We sought to determine the effects of selenium (Se) on acrylamide (ACR)-induced
nephrotoxicity in rats. In our study, 50 adult male Sprague-Dawley rats weighing 200–250 g …

Lactoferrin alleviates cyclophosphamide induced-nephropathy through suppressing the orchestration between Wnt4/β-catenin and ERK1/2/NF-κB signaling and …

OS Mohamed, NAA Baky, MM Sayed-Ahmed… - Life Sciences, 2023 - Elsevier
Aims Cyclophosphamide is an alkylating agent with vast arrays of therapeutic activity.
Currently, its medical use is limited due to its numerous adverse events, including …

Protective effects of hesperidin in cyclophosphamide-induced parotid toxicity in rats

OAA Mostafa, F Ibrahim, E Borai - Scientific Reports, 2023 - nature.com
Cyclophosphamide (CYP) is an alkylating agent that is used on a wide range as a treatment
of malignancies and autoimmune diseases. Previous studies have shown the promising role …

Dietary selenomethionine ameliorates lipopolysaccharide-induced renal inflammatory injury in broilers via regulating the PI3K/AKT pathway to inhibit necroptosis

Y Zhang, X Qi, X Chen, J Zhang, W Zhang, H Lin - Food & function, 2021 - pubs.rsc.org
Selenomethionine (SeMet) has antioxidant and anti-inflammatory effects, as a widely used
organic Se source in food supplements, and its inhibitory effect on the prevention and …

Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis via targeting Sphk1/S1P/MAPK, TLR-4/NF-κB, and NLRP3/caspase-1/IL-1β …

NAA Baky, AH Al-Najjar, HA Elariny, AS Sallam… - International …, 2022 - Elsevier
Background The use of cyclophosphamide (CP) as a chemotherapeutic agent is limited by
its major complication haemorrhagic cystitis (HC). Finding preventive, safe, and efficient …

Thymoquinone alleviates mitochondrial viability and apoptosis in diclofenac-induced acute kidney injury (AKI) via regulating Mfn2 and miR-34a mRNA expressions

KS Hashem, AZ Abdelazem, MA Mohammed… - … Science and Pollution …, 2021 - Springer
The current study was prepared to assess the underlying mechanism of diclofenac (Diclo)-
stimulated renal oxidative damage (50 mg/kg/day for two consecutive days IP) and …

Ameliorative effect of herbacetin against cyclophosphamide-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and …

MU Ijaz, S Mustafa, R Batool, H Naz… - Human & …, 2022 - journals.sagepub.com
Herbacetin (HBN) is a glycosylated flavonoid, which possesses numerous pharmacological
properties. Cyclophosphamide (CYC) is a chemotherapeutic drug that adversely affects the …

Biochemical, histological, and ultrastructural studies of the protective role of vitamin E on cyclophosphamide-induced cardiotoxicity in male rats

AA Attia, JM Sorour, NA Mohamed, TT Mansour… - Biomedicines, 2023 - mdpi.com
Background: Cyclophosphamide (CP)(Cytoxan or Endoxan) is an efficient anti-tumor agent,
widely used for the treatment of various neoplastic diseases. The study aimed to investigate …