Polysaccharide-based polyelectrolyte complex nanoparticles from chitosan, heparin, and hyaluronan

S Boddohi, N Moore, PA Johnson… - Biomacromolecules, 2009 - ACS Publications
The formation of polyelectrolyte complex nanoparticles (PCN) was investigated at different
charge mixing ratios for the chitosan-heparin (chi-hep) and chitosan-hyaluronan (chi-ha) …

Kinetics of different processes in human insulin amyloid formation

M Manno, EF Craparo, A Podestà, D Bulone… - Journal of molecular …, 2007 - Elsevier
Human insulin has long been known to form amyloid fibrils under given conditions. The
molecular basis of insulin aggregation is relevant for modeling the amyloidogenesis …

Multiscale characterization of individualized β-lactoglobulin microgels formed upon heat treatment under narrow pH range conditions

C Schmitt, C Bovay, AM Vuilliomenet, M Rouvet… - Langmuir, 2009 - ACS Publications
Aqueous dispersions of demineralized β-lactoglobulin (β-lg) were held at 85° C for 15 min at
a constant protein concentration of 1 wt% in the pH range of 3.0− 7.0. This led to denatured …

[HTML][HTML] Methodology for sample preparation and size measurement of commercial ZnO nanoparticles

PJ Lu, WE Fu, SC Huang, CY Lin, ML Ho… - Journal of food and drug …, 2018 - Elsevier
This study discusses the strategies on sample preparation to acquire images with sufficient
quality for size characterization by scanning electron microscope (SEM) using two …

Micellization Phenomena of Amphiphilic Block Copolymers Based on Methoxy Poly(ethylene glycol) and Either Crystalline or Amorphous Poly(caprolactone-b-lactide …

J Zhang, LQ Wang, H Wang, K Tu - Biomacromolecules, 2006 - ACS Publications
This study focuses on the aggregation behavior of the biodegradable amphiphilic block
copolymers based on methoxy poly (ethylene glycol)(mPEG) as a hydrophilic block and …

DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers

D Oupický, Č Koňák, K Ulbrich, MA Wolfert… - Journal of Controlled …, 2000 - Elsevier
Block and graft copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) with 2-
(trimethylammonio) ethyl methacrylate were synthesised and used for preparation of …

Role of membrane features on the permeability behavior of polymersomes and the potential impacts on drug encapsulation and release

FA de Oliveira, CCS Batista, P Cernoch… - …, 2023 - ACS Publications
Self-assembled bilayer structures such as those produced from amphiphilic block
copolymers (polymersomes) are potentially useful in a wide array of applications including …

Structure and dynamics of single-chain nano-particles in solution

A Arbe, JA Pomposo, AJ Moreno, F LoVerso… - Polymer, 2016 - Elsevier
By means of intramolecular folding/collapse of individual polymer chains (precursors), ultra-
small soft nano-objects called single-chain nano-particles (SCNPs) can be synthesized …

[HTML][HTML] Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates

P Picone, S Vilasi, F Librizzi, M Contardi… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
The onset of Alzheimer disease (AD) is influenced by several risk factors comprising
diabetes. Within this context, antidiabetic drugs, including metformin, are investigated for …

Solid lipid nanoparticles for hydrophilic biotech drugs: Optimization and cell viability studies (Caco-2 & HEPG-2 cell lines)

P Severino, T Andreani, A Jäger, MV Chaud… - European journal of …, 2014 - Elsevier
Insulin was used as model protein to developed innovative Solid Lipid Nanoparticles (SLNs)
for the delivery of hydrophilic biotech drugs, with potential use in medicinal chemistry. SLNs …