T cell subsets are critically involved in the development of systemic autoimmunity and organ
inflammation in systemic lupus erythematosus (SLE). Each T cell subset function (such as …

Systemic lupus erythematosus (SLE) is an autoimmune disease mediated by pathogenic
autoantibodies directed against nucleoprotein complexes. Beyond the activation of …

Glycosphingolipids (GSLs) exhibit a variety of functions in cellular differentiation and
interaction. Also, they are known to play a role as receptors in pathogen invasion. A less well …

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation …

Abstract Purpose Transglutaminases (TGs) are multifunctional enzymes exhibiting
transglutaminase crosslinking, as well as atypical GTPase/ATPase and kinase activities …

Graft-versus-host disease (GVHD), manifesting as either acute (aGVHD) or chronic
(cGVHD), presents significant life-threatening complications following allogeneic …

Nearly one half of patients with lupus develop glomerulonephritis (GN), which often leads to
renal failure. Although nephritis is diagnosed by the presence of proteinuria, the pathology …

In the normal immune system, T cell activation is tightly regulated and controlled at several
levels to ensure that activation occurs in the right context to prevent the development of …

Hemorrhagic viral diseases are distributed worldwide with important pathogens, such as
dengue virus or hantaviruses. The lack of adequate in vivo infection models has limited the …

Mammalian neuraminidases (NEUs), also known as sialidases, are enzymes that cleave off
the terminal neuraminic, or sialic, acid resides from the carbohydrate moieties of glycolipids …