Proposed US regulation of gene-edited food animals is not fit for purpose

AL Van Eenennaam, KD Wells, JD Murray - npj Science of Food, 2019 - nature.com
Dietary DNA is generally regarded as safe to consume, and is a routine ingredient of food
obtained from any living organism. Millions of naturally-occurring DNA variations are …

Plant genome editing and the relevance of off-target changes

N Graham, GB Patil, DM Bubeck, RC Dobert… - Plant …, 2020 - academic.oup.com
Site-directed nucleases (SDNs) used for targeted genome editing are powerful new tools to
introduce precise genetic changes into plants. Like traditional approaches, such as …

Development and screening of EMS mutants with altered seed oil content or fatty acid composition in Brassica napus

S Tang, DX Liu, S Lu, L Yu, Y Li, S Lin, L Li… - The Plant …, 2020 - Wiley Online Library
Brassica napus is an important oilseed crop in the world, and the mechanism of seed oil
biosynthesis in B. napus remains unclear. In order to study the mechanism of oil …

Cultivar-specific markers, mutations, and chimerisim of Cavendish banana somaclonal variants resistant to Fusarium oxysporum f. sp. cubense tropical race 4

BH Hou, YH Tsai, MH Chiang, SM Tsao, SH Huang… - BMC genomics, 2022 - Springer
Background The selection of tissue culture–derived somaclonal variants of Giant Cavendish
banana (Musa spp., Cavendish sub-group AAA) by the Taiwan Banana Research Institute …

Metabolic profiling of a fast neutron soybean mutant reveals an increased abundance of isoflavones

N Islam, HB Krishnan, J Slovin… - Journal of Agricultural …, 2023 - ACS Publications
A total of 718 metabolites were identified in leaves and seeds of the soybean (Glycine max
(L.) Merr., Fabaceae) fast neutron (FN) mutant 2012CM7F040p05ar154bMN15, which was …

Fast neutron mutagenesis in soybean enriches for small indels and creates frameshift mutations

SR Wyant, MF Rodriguez, CK Carter, WA Parrott… - G3, 2022 - academic.oup.com
The mutagenic effects of ionizing radiation have been used for decades to create novel
variants in experimental populations. Fast neutron (FN) bombardment as a mutagen has …

Metabolite profiling of a high protein fast neutron soybean mutant revealed increased storage of methionine and flavonoids

N Islam, HB Krishnan, JC Jones, S Natarajan - Crop Science, 2024 - Wiley Online Library
In this study, we used mass spectrometry (MS)‐based techniques to assess the metabolic
profile of fast neutron–radiated soybean (Glycine max) seeds that had higher protein …

A novel repetition frequency-based DNA encoding scheme to predict human and mouse DNA enhancers with deep learning

TB Alakuş - Biomimetics, 2023 - mdpi.com
Recent studies have shown that DNA enhancers have an important role in the regulation of
gene expression. They are responsible for different important biological elements and …

Non‐targeted metabolite profiling of a fast neutron soybean mutant reveals an increase in sulfur‐containing metabolites

N Islam, HB Krishnan, J Slovin, S Natarajan - Crop Science, 2024 - Wiley Online Library
Abstract Soybean [Glycine max (L.) Merr] seed is a valuable source of raw materials of
protein, oil, and metabolites for food, feed, and pharmaceutical industries. Using global …

Sodium azide mutagenesis induces a unique pattern of mutations

C Liu, G Frascarelli, AO Stec, S Heinen, L Lei… - bioRxiv, 2024 - biorxiv.org
The nature and effect of mutations are of fundamental importance to the evolutionary
process. The generation of mutations with mutagens has also played important roles in …