Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

One of the commonest and least well understood posttranslational modifications of proteins
is their glycosylation. Human glycoproteins are glycosylated with a bewilderingly …

Haemophilia B is a X-chromosome linked disease characterised by a deficiency of
functionally active coagulation Factor IX (FIX). Patients with severe haemophilia B at risk of …

A comparative study was performed on heparin resins and strong and weak cation
exchangers to investigate the pH dependence, efficiency, binding strength, particle size …

BACKGROUND AND OBJECTIVES: Autoantibodies inactivating the von Willebrand factor
(VWF) cleaving protease, ADAMTS-13, are among the most frequent causes of thrombotic …

The past 10 years of clinical experience have demonstrated the safety and efficacy of
recombinant clotting factors. With the adoption of prophylactic strategies, there has been …

Nucleic acid aptamers are promising ligands for analytical and preparative-scale affinity
chromatography applications. However, a full industrial exploitation requires that aptamer …

The ability to genetically modify pigs has enabled scientists to create pigs that are beneficial
to humans in ways that were previously unimaginable. Improvements in the methods to …

Appropriate glycosylation of recombinant therapeutic glycoproteins has been emphasized in
biopharmaceutical industries because the carbohydrate component can affect safety …

Recombinant DNA technology and protein engineering are creating hope that we can
address ongoing challenges in hemophilia care such as reducing the costs of therapy …