A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

Z He, Y Hu, Z Niu, K Zhong, T Liu, M Yang, L Ji… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Centella asiatica (L.) Urb., a potential medicinal plant, is
widely used in orient traditional medicine. Its major active constituents include asiaticoside …

A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study

M Ahda, I Jaswir, A Khatib, QU Ahmed… - … journal of food …, 2023 - Taylor & Francis
Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal
drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of …

Computational studies on carbazole-pyranocoumarin conjugate against α-glucosidase enzyme

MI Abdjan, NS Aminah, AN Kristanti, I Siswanto… - Engineered …, 2024 - espublisher.com
Abstract α-Glucosidase is an enzyme responsible for releasing the α-D-glucose monomer
through hydrolysis reactions. The release of this monomer increases the sugar …

Advancing one health vaccination: In silico design and evaluation of a multi-epitope subunit vaccine against Nipah virus for cross-species immunization using …

EC Banico, EMJS Sira, LE Fajardo, ANG Dulay… - PloS one, 2024 - journals.plos.org
The resurgence of the Nipah virus (NiV) in 2023 has raised concerns for another potentially
severe pandemic, given its history of high mortality from previous outbreaks. Unfortunately …

Asiaticoside prevents oxidative stress and apoptosis in endothelial cells by activating ROS-dependent p53/bcl-2/caspase-3 signaling pathway

Z Liang, Y Chen, R Gu, Q Guo… - Current molecular …, 2023 - ingentaconnect.com
Background: Asiaticoside (AC) is a triterpenoid saponin found in Centella asiatica (L.) urban
extract that has a wide range of pharmacological properties. Our previous study …

Repurposing of phyto-ligand molecules from the honey bee products for Alzheimer's disease as novel inhibitors of BACE-1: Small molecule bioinformatics strategies …

N Nisa, B Rasmita, C Arati, C Uditraj… - … Science and Pollution …, 2023 - Springer
Alzheimer's disease (AD) is one of the neurodegenerative diseases, manifesting dementia,
spatial disorientation, language, cognitive, and functional impairment, mainly affects the …

Protective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro

S Tang, X Xie, M Wang, L Yang, W Wei - Bioengineered, 2022 - Taylor & Francis
Ischemia/reperfusion injury (I/R) is the main causes of acute kidney injury (AKI), which is a
global health concern. Evidence suggests that asiaticoside plays vital roles on anti …

Uncovering the antidiabetic potential of heart-friendly and diuretic bioactive compounds through computer-based drug design

N Ercin, N Besli, U Kilic - Computational biology and chemistry, 2024 - Elsevier
Avicenna, a pioneer of modern medicine, recommended diuretic therapy to treat diabetes.
Like Avicenna's approach, current medicine frequently prescribes oral antidiabetic pills with …

[PDF][PDF] Update Review: Extraction, Purification, and Pharmacological Activities of Gotu Kola Terpenoids

N Amalia, FN Okta, AA Zahra… - Lett Appl …, 2024 - nanobioletters.com
Centella asiatica, which belongs to the family Apiceae, is widely used in cosmetics
manufacturing and the drug industry. Centella asiatica contains many chemical compounds …

The potential of Chlorella spp. as antiviral source against African swine fever virus through a virtual screening pipeline

ANG Dulay, JCC de Guzman, ZYD Marquez… - Journal of Molecular …, 2024 - Elsevier
African swine fever (ASF) causes high mortality in pigs and threatens global swine
production. There is still a lack of therapeutics available, with two vaccines under scrutiny …