Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

The primary cilium is an antenna-like, immotile organelle present on most types of
mammalian cells, which interprets extracellular signals that regulate growth and …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

The cilium, once considered a vestigial structure, is a conserved, microtubule-based
organelle critical for transducing extracellular chemical and mechanical signals that control …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Parkinson's disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases,
including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia …

Intraflagellar transport (IFT) is a form of motor‐dependent cargo transport that is essential for
the assembly, maintenance, and length control of cilia, which play critical roles in motility …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …