Two decades of Martini: Better beads, broader scope
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …
been around for nearly two decades. Originally developed for lipid‐based systems by the …
[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction
V Kalienkova, VC Mosina, C Paulino - Journal of Molecular Biology, 2021 - Elsevier
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …
while some family members function as Ca 2+-activated anion channels, the majority of …
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2
SARS-CoV-2 has been spreading around the world for the past year. Recently, several
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …
variants such as B. 1.1. 7 (alpha), B. 1.351 (beta), and P. 1 (gamma), which share a key …
Elevator-type mechanisms of membrane transport
AA Garaeva, DJ Slotboom - Biochemical Society Transactions, 2020 - portlandpress.com
Membrane transporters are integral membrane proteins that mediate the passage of solutes
across lipid bilayers. These proteins undergo conformational transitions between outward …
across lipid bilayers. These proteins undergo conformational transitions between outward …
Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
V Arkhipova, A Guskov, DJ Slotboom - Nature communications, 2020 - nature.com
Glutamate transporters are cation-coupled secondary active membrane transporters that
clear the neurotransmitter L-glutamate from the synaptic cleft. These transporters are …
clear the neurotransmitter L-glutamate from the synaptic cleft. These transporters are …
Glutamate transporters have a chloride channel with two hydrophobic gates
Glutamate is the most abundant excitatory neurotransmitter in the central nervous system,
and its precise control is vital to maintain normal brain function and to prevent excitotoxicity …
and its precise control is vital to maintain normal brain function and to prevent excitotoxicity …
[HTML][HTML] The mannose phosphotransferase system (Man-PTS)-Mannose transporter and receptor for bacteriocins and bacteriophages
JM Jeckelmann, B Erni - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Mannose transporters constitute a superfamily (Man-PTS) of the Phosphoenolpyruvate
Carbohydrate Phosphotransferase System (PTS). The membrane complexes are …
Carbohydrate Phosphotransferase System (PTS). The membrane complexes are …
Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters
X Wang, O Boudker - Elife, 2020 - elifesciences.org
Glutamate transporters are essential players in glutamatergic neurotransmission in the
brain, where they maintain extracellular glutamate below cytotoxic levels and allow for …
brain, where they maintain extracellular glutamate below cytotoxic levels and allow for …
CryoFold: Determining protein structures and data-guided ensembles from cryo-EM density maps
Cryoelectron microscopy requires molecular modeling for refinement of structures.
Ensemble models arrive at low free-energy molecular structures, but are computationally …
Ensemble models arrive at low free-energy molecular structures, but are computationally …
Millisecond dynamics of an unlabeled amino acid transporter
Excitatory amino acid transporters (EAATs) are important in many physiological processes
and crucial for the removal of excitatory amino acids from the synaptic cleft. Here, we …
and crucial for the removal of excitatory amino acids from the synaptic cleft. Here, we …