Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT)
gene. The mechanism (s) by which mutant HTT (mHTT) causes disease is unclear …

Defects in nucleocytoplasmic transport have been associated with several
neurodegenerative disorders and, in particular, the formation of pathological protein …

Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in
eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis …

The integration of circadian and metabolic signals is essential for maintaining robust
circadian rhythms and ensuring efficient metabolism and energy use. Using Drosophila as …

Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier between
nucleoplasm and cytoplasm. Nucleoporins also localize in cytoplasmic foci proposed to …

The spatial separation of protein synthesis from the compartmental destiny of proteins led to
the evolution of transport systems that are efficient and yet highly specific. Co-translational …

Protein O-GlcNAcylation plays critical roles in many cellular events, and its dysregulation is
related to multiple diseases. Integrating bioorthogonal chemistry and multiplexed …

O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological
processes and is dysregulated in human diseases. Despite this broad pathophysiological …