[HTML][HTML] Preclinical models for neuroblastoma: Advances and challenges
Neuroblastoma is a paediatric cancer of the sympathetic nervous system and the most
common solid tumour of infancy, contributing to 15% of paediatric oncology deaths. Current …
common solid tumour of infancy, contributing to 15% of paediatric oncology deaths. Current …
Cell-laden hydrogel as a clinical-relevant 3D model for analyzing neuroblastoma growth, immunophenotype, and susceptibility to therapies
High risk Neuroblastoma (NB) includes aggressive, metastatic solid tumors of childhood.
The survival rate improved only modestly, despite the use of combination therapies …
The survival rate improved only modestly, despite the use of combination therapies …
Local and global sensitivity analysis of spheroid and xenograft models of the acid-mediated development of tumor malignancy
F Rentzeperis, D Wallace - Applied Mathematical Modelling, 2022 - Elsevier
An ODE model of tumor growth incorporating microenvironmental acidosis, hypoxia,
angiogenesis, and necrosis is proposed. Local and global sensitivity analyses show that the …
angiogenesis, and necrosis is proposed. Local and global sensitivity analyses show that the …
Predictive modeling of neuroblastoma growth dynamics in xenograft model after bevacizumab anti-VEGF therapy
Y He, A Kodali, DI Wallace - Bulletin of Mathematical Biology, 2018 - Springer
Neuroblastoma is the leading cause of cancer death in young children. Although treatment
for neuroblastoma has improved, the 5-year survival rate of patients still remains less than …
for neuroblastoma has improved, the 5-year survival rate of patients still remains less than …
Targeting cellular DNA damage responses in cancer: an in vitro-calibrated agent-based model simulating monolayer and spheroid treatment responses to ATR …
We combine a systems pharmacology approach with an agent-based modelling approach to
simulate LoVo cells subjected to AZD6738, an ATR (ataxia–telangiectasia-mutated and rad3 …
simulate LoVo cells subjected to AZD6738, an ATR (ataxia–telangiectasia-mutated and rad3 …
Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts
F Rentzeperis, B Coleman, D Wallace - AppliedMath, 2024 - mdpi.com
Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing
suppression of tumor growth, if cells are synchronized in a specific phase. A model is …
suppression of tumor growth, if cells are synchronized in a specific phase. A model is …
On a 2d model of avascular tumor with weak allee effect
Recent studies reveal that Allee effect may play important roles in the growth of tumor. We
present one of the first mathematical models of avascular tumor that incorporates the weak …
present one of the first mathematical models of avascular tumor that incorporates the weak …
A simulation of parental and glycolytic tumor phenotype competition predicts observed responses to pH changes and increased glycolysis after anti-VEGF therapy
F Rentzeperis, N Miller, A Ibrahim-Hashim… - Mathematical …, 2022 - Elsevier
Clinical cancers are typically spatially and temporally heterogeneous, containing multiple
microenvironmental habitats and diverse phenotypes and/or genotypes, which can interact …
microenvironmental habitats and diverse phenotypes and/or genotypes, which can interact …
Predicting the results of competition between two breast cancer lines grown in 3-D spheroid culture
This study develops a novel model of a consumer–resource system with mobility included, in
order to explain a novel experiment of competition between two breast cancer cell lines …
order to explain a novel experiment of competition between two breast cancer cell lines …
Erratum to “A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2”
DI Wallace, A Dunham, PX Chen, M Chen… - … Methods in Medicine, 2017 - ncbi.nlm.nih.gov
Erratum to “A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma
Cells to Treatment with 15-Deoxy-PGJ2” - PMC Back to Top Skip to main content NIH NLM …
Cells to Treatment with 15-Deoxy-PGJ2” - PMC Back to Top Skip to main content NIH NLM …