Brain microvascular pericytes in vascular cognitive impairment and dementia

MT Uemura, T Maki, M Ihara, VMY Lee… - Frontiers in aging …, 2020 - frontiersin.org
Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …

Cardiovascular comorbidities, inflammation, and cerebral small vessel disease

LE Evans, JL Taylor, CJ Smith… - Cardiovascular …, 2021 - academic.oup.com
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Cerebral small vessel disease: Pathological mechanisms and potential therapeutic targets

Y Gao, D Li, J Lin, AM Thomas, J Miao… - Frontiers in aging …, 2022 - frontiersin.org
Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis …

A vessel for change: endothelial dysfunction in cerebral small vessel disease

S Quick, J Moss, RM Rajani, A Williams - Trends in neurosciences, 2021 - cell.com
The blood vessels of the brain are lined with endothelial cells and it has been long known
that these help to regulate blood flow to the brain. However, there is increasing evidence …

Notch signalling in healthy and diseased vasculature

F Del Gaudio, D Liu, U Lendahl - Open Biology, 2022 - royalsocietypublishing.org
Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

[HTML][HTML] Cerebral small vessel disease–related dementia: more questions than answers

FM Elahi, MM Wang, JF Meschia - Stroke, 2023 - journals.lww.com
Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …

[HTML][HTML] Interplay between brain pericytes and endothelial cells in dementia

TV Procter, A Williams, A Montagne - The American Journal of Pathology, 2021 - Elsevier
Prevalence of dementia continues to increase because of the aging population and limited
treatment options. Cerebral small vessel disease and Alzheimer disease are the two most …

PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity

F Dabertrand, OF Harraz, M Koide… - Proceedings of the …, 2021 - National Acad Sciences
Cerebral small vessel diseases (SVDs) are a central link between stroke and dementia—two
comorbidities without specific treatments. Despite the emerging consensus that SVDs are …

CADASIL affects multiple aspects of cerebral small vessel function on 7T‐MRI

H Van Den Brink, A Kopczak, T Arts… - Annals of …, 2023 - Wiley Online Library
Objective Cerebral small vessel diseases (cSVDs) are a major cause of stroke and
dementia. We used cutting‐edge 7T‐MRI techniques in patients with Cerebral Autosomal …

White matter damage as a consequence of vascular dysfunction in a spontaneous mouse model of chronic mild chronic hypoperfusion with eNOS deficiency

X Chen, L Chen, G Lin, Z Wang, MC Kodali, M Li… - Molecular …, 2022 - nature.com
Vascular cognitive impairment and dementia (VCID) is the second most common form of
dementia after Alzheimer's disease (AD). Currently, the mechanistic insights into the …