Background It has been suggested that a time‐lag bias exists whereby research studies with
striking results are more likely to be stopped earlier than originally planned, published …

Breast cancer is a multifactorial disease that affects millions of women worldwide. Recent
work has shown intriguing connections between microorganisms and breast cancer, which …

This paper studies how competitive dynamics shape innovative firms' voluntary disclosure of
product quality information. Our empirical context is the pharmaceutical industry, where firms …

Importance Clinical trials are the path to test and introduce new therapies in the clinic. Trials
that are unable to produce results represent inefficiency in the system and may also …

Importance Publishing study protocols might reduce research waste because of unclear
methods or incomplete reporting; on the other hand, there might be few additional benefits of …

Across fields, the quantity of research has increased substantially, without an attendant
increase in output. We argue that, in medicine, this indicator of declining productivity reflects …

In the last two decades several requirements have been developed to enhance clinical trials
transparency. Some are encouraged or recommended by ethics codes, journal editors, or …

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced NSCLC.
1 Despite improvements in survival, most will develop tumor resistance, and approaches to …

Innovations often combine several components to achieve outcomes greater than the “sum
of the parts.” We argue that such combination innovations can introduce an understudied …

For this study, researchers evaluated 10,442 cancer trials that were registered on
ClinicalTrials. gov and completed between 2008 and 2021. The researchers assessed …