Biodegradable polymeric nanoparticles for drug delivery to solid tumors

A Gagliardi, E Giuliano, E Venkateswararao… - Frontiers in …, 2021 - frontiersin.org
Advances in nanotechnology have favored the development of novel colloidal formulations
able to modulate the pharmacological and biopharmaceutical properties of drugs. The …

The effects of protein corona on in vivo fate of nanocarriers

Q Xiao, M Zoulikha, M Qiu, C Teng, C Lin, X Li… - Advanced Drug Delivery …, 2022 - Elsevier
With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

Why nanoparticles prefer liver macrophage cell uptake in vivo

W Ngo, S Ahmed, C Blackadar, B Bussin, Q Ji… - Advanced Drug Delivery …, 2022 - Elsevier
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Coronas of micro/nano plastics: a key determinant in their risk assessments

J Cao, Q Yang, J Jiang, T Dalu, A Kadushkin… - Particle and Fibre …, 2022 - Springer
As an emerging pollutant in the life cycle of plastic products, micro/nanoplastics (M/NPs) are
increasingly being released into the natural environment. Substantial concerns have been …

Nanotherapeutics for nose-to-brain drug delivery: an approach to bypass the blood brain barrier

D Lee, T Minko - Pharmaceutics, 2021 - mdpi.com
Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders
has always been a significant challenge. The nature of the blood-brain barrier (BBB) limits …

Understanding the lipid and protein corona formation on different sized polymeric nanoparticles

T Lima, K Bernfur, M Vilanova, T Cedervall - Scientific reports, 2020 - nature.com
When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like
proteins and lipids onto their surface, forming a “corona”. This biocorona is a dynamic and …

Interface-driven hybrid materials based on DNA-functionalized gold nanoparticles

B Liu, J Liu - Matter, 2019 - cell.com
DNA-functionalized gold nanoparticles (AuNPs) are popular hybrid materials with
applications in directed assembly, biosensor development, and drug delivery. This system is …

Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities

AA Ashkarran, H Gharibi, E Voke, MP Landry… - Nature …, 2022 - nature.com
Robust characterization of the protein corona—the layer of proteins that spontaneously
forms on the surface of nanoparticles immersed in biological fluids—is vital for prediction of …

Lipid nanoparticle spherical nucleic acids for intracellular DNA and RNA delivery

AJ Sinegra, M Evangelopoulos, J Park, Z Huang… - Nano …, 2021 - ACS Publications
Lipid nanoparticle SNAs (LNP-SNAs) have been synthesized for the delivery of DNA and
RNA to targets in the cytoplasm of cells. Both the composition of the LNP core and surface …