The need for new antibiotic therapies is acute and growing in large part because of the
emergence of drug-resistant pathogens. A vast number of resistance determinants are …

It is well established that lipid metabolism is drastically altered during tumor development
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …

Lipid droplets are important for cancer cell growth and survival. However, the mechanism
underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here …

Aberrantly upregulated choline phospholipid metabolism is a novel emerging hallmark of
cancer, and choline kinase α (CHKα), a key enzyme for phosphatidylcholine production, is …

Choline is a precursor of cellular phospholipid metabolism that provides Magnetic
Resonance (MR) and Positron Emission Tomography (PET) biomarkers for cancer detection …

Background The Kennedy pathway generates phosphocoline and phosphoethanolamine
through its two branches. Choline Kinase (ChoK) is the first enzyme of the Kennedy branch …

Choline is an essential anabolic substrate for the synthesis of phospholipids. Choline kinase
phosphorylates choline to phosphocholine that serves as a precursor for the production of …

Epidermal growth factor receptor (EGFR) family members and c-Src are co-overexpressed in
many cancers. The synergistic effect of EGFR and c-Src has been shown in the …

Choline kinase-α expression and activity are increased in multiple human neoplasms as a
result of growth factor stimulation and activation of cancer-related signaling pathways. The …

Digital enzyme assays are emerging biosensing methods for highly sensitive quantitative
analysis of biomolecules with single-molecule detection sensitivity. However, current digital …