Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

Diseases/conditions with diverse etiology, such as hemoglobinopathies, hereditary
hemochromatosis and menopause, could lead to chronic iron accumulation. This condition …

Osteoclasts are acid-secreting polykaryons that have high energy demands and contain
abundant mitochondria. How mitochondrial biogenesis is integrated with osteoclast …

Coculture of osteoblasts and osteoclasts is a subject of interest in the understanding of how
magnesium (Mg)-based implants influence the bone metabolism and remodeling upon …

Osteogenic differentiation of multipotent mesenchymal stem cells (MSCs) plays a crucial role
in bone remodeling. Numerous studies have described the deleterious effect of iron …

Osteoporosis represents an important cause of morbidity in adult patients with thalassaemia
major (TM). The pathogenesis of osteoporosis in TM is multifactorial, and includes bone …

The life of patients with thalassemia has improved both in duration and in quality in
industrialized countries. Complications are still common and include heart disease (heart …

Background Osteoprotegerin (OPG) and receptor activator of nuclear factor κ B ligand
(RANKL) play a critical role in the regulation of bone turnover, but the relative importance of …

Increased survival in patients with β thalassemia major (TM) allowed for several
complications of the disease and its treatment to manifest, one of which is bone disease …

Thalassemia bone disease is a common and severe complication of thalassemia—an
inherited blood disorder due to mutations in the α or β hemoglobin gene. In its more severe …