Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical
and molecular features with a wide variety of human cancers, making this companion animal …

Background/Aim: Betulinic acid (BA) and betulin (BT) exhibit a variety of pharmacological
properties including anti-cancer, anti-inflammatory and anti-oxidant ones. Canine lymphoma …

Methotrexate (MTX) therapy encounters significant limitations due to the significant concern
of drug-induced liver injury (DILI), which poses a significant challenge to its usage. To …

Objectives Hepatotoxicity is a severe outcome of methotrexate (MTX) therapy, limiting its
clinical use and contributing to its related morbidity and mortality. This study investigated the …

Methotrexate (MTX) is widely used to treat cancers and systemic autoimmune diseases.
However, it is severely toxic to healthy cells, especially those of the reproductive system, and …

Objectives The relationship between rheumatoid arthritis (RA) and the risk of leukemia was
still controversial. This study aimed to assess the risk of leukemia in patients with rheumatoid …

T-cell lymphomas (TCLs) are a malignancy characterized by tumor aggression and
resistance to traditional chemotherapy. Disruption of the extrinsic cell death pathway is …

Canine B-cell lymphoma (CBL) is an incurable, spontaneous lymphoid malignancy
constituting an accurate animal model for testing novel therapeutic strategies in human …

Intrathecal chemotherapy is used in human medicine for the treatment or prophylaxis of CNS
hematopoietic neoplasia. However, the clinical benefits in veterinary medicine have been …

The canine transmissible venereal tumor (CTVT) is the most common malignity in dogs.
Because there are reports that this tumor is resistant to vincristine sulfate, the …