SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and …
S Temmam, K Vongphayloth, E Baquero, S Munier… - Nature, 2022 - nature.com
The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related viruses in Asian Rhinolophus bats,,–, including the closest virus from R. affinis, RaTG13 …
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA. 1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …
H Gruell, K Vanshylla, P Tober-Lau, D Hillus… - Nature medicine, 2022 - nature.com
The Omicron variant of SARS-CoV-2 is causing a rapid increase in infections across the globe. This new variant of concern carries an unusually high number of mutations in key …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or …
Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural evolutionary strategies could guide …
JE Bowen, A Addetia, HV Dang, C Stewart, JT Brown… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA. 2 and BA. 2.12. 1 having replaced the …
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain (RBD) of the spike protein. The effects of these mutations on …
An ideal therapeutic anti-SARS-CoV-2 antibody would resist viral escape,–, have activity against diverse sarbecoviruses,,–, and be highly protective through viral neutralization,,–and …