TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
Signaling pathways drive cell fate transitions largely by changing gene expression.
However, the mechanisms for rapid and selective transcriptome rewiring in response to …
However, the mechanisms for rapid and selective transcriptome rewiring in response to …
NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity
Abstract Tudor Interacting Repair Regulator (TIRR) is an RNA-binding protein (RBP) that
interacts directly with 53BP1, restricting its access to DNA double-strand breaks (DSBs) and …
interacts directly with 53BP1, restricting its access to DNA double-strand breaks (DSBs) and …
N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast
RA Varier, T Sideri, C Capitanchik, Z Manova… - Elife, 2022 - elifesciences.org
Abstract N6-methyladenosine (m6A) RNA modification impacts mRNA fate primarily via
reader proteins, which dictate processes in development, stress, and disease. Yet little is …
reader proteins, which dictate processes in development, stress, and disease. Yet little is …
An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene
MS Azman, EL Alard, M Dodel, F Capraro… - The EMBO …, 2023 - embopress.org
Oncogenic RAS signaling reprograms gene expression through both transcriptional and
post‐transcriptional mechanisms. While transcriptional regulation downstream of RAS is …
post‐transcriptional mechanisms. While transcriptional regulation downstream of RAS is …
Transcriptome-wide RNA binding analysis of C9orf72 poly (PR) dipeptides
R Balendra, IR de Los Mozos, HM Odeh… - Life Science …, 2023 - life-science-alliance.org
An intronic GGGGCC repeat expansion in C9orf72 is a common genetic cause of
amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in …
amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in …
The FXR1 network acts as a signaling scaffold for actomyosin remodeling
It is currently not known whether mRNAs fulfill structural roles in the cytoplasm. Here, we
report the fragile X-related protein 1 (FXR1) network, an mRNA-protein (mRNP) network …
report the fragile X-related protein 1 (FXR1) network, an mRNA-protein (mRNP) network …
Interrogation of RNA-protein interaction dynamics in bacterial growth
Characterising RNA–protein interaction dynamics is fundamental to understand how
bacteria respond to their environment. In this study, we have analysed the dynamics of 91 …
bacteria respond to their environment. In this study, we have analysed the dynamics of 91 …
Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP
SA Manakov, AA Shishkin, BA Yee, KA Shen, DC Cox… - BioRxiv, 2022 - biorxiv.org
Our expanding knowledge of the roles small regulatory RNAs play across numerous areas
of biology, coupled with the promise of RNA-targeted therapies and small RNA-based …
of biology, coupled with the promise of RNA-targeted therapies and small RNA-based …
[HTML][HTML] nf-core/clipseq-a robust Nextflow pipeline for comprehensive CLIP data analysis
Crosslinking and immunoprecipitation (CLIP) technologies have become a central
component of the molecular biologists' toolkit to study protein-RNA interactions and thus to …
component of the molecular biologists' toolkit to study protein-RNA interactions and thus to …