Bone fracture is a very common body injury. The healing process is physiologically complex,
involving both biological and mechanical aspects. Following a fracture, cell migration …

Abstract Objectives Bone morphogenetic proteins (BMPs), more specifically BMP-2, are
being increasingly used in orthopaedic surgery due to advanced research into …

Natural tissues possess a so-called J-shaped strain-stiffening behavior, being soft and
compliant at small strains followed by a rapid stiffening at higher strains to prevent tissue …

The direct injection of bone marrow mesenchymal stem cells (hMSCs) is a promising
strategy for bone tissue engineering applications. Herein, we have developed injectable …

Abstract Bone morphogenetic protein-2 (BMP-2), delivered on absorbable collagen sponge,
is frequently used to treat bone defects. However, supraphysiological BMP-2 doses are …

Substantial tissue loss, such as in large bone defects, represents a clinical challenge for
which regenerative therapies and tissue engineering strategies aim at offering treatment …

Mechanical environment has a crucial role in our organism at the different levels, ranging
from cells to tissues and our own organs. This regulatory role is especially relevant for …

Bioceramics are widely considered as elective materials for the regeneration of bone tissue,
due to their compositional mimicry with bone inorganic components. However, they are …

The basic concepts from the fields of biology and engineering are integrated into tissue
engineering to develop constructs for the repair of damaged and/or absent tissues …

Bone regeneration is strongly dependent on the capacity of cells to move in a 3D
microenvironment, where a large cascade of signals is activated. To improve the …