Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects
approximately 24% to 40% of the population of the Western world. In addition to its well …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Microcirculation and macrocirculation are tightly interconnected into a dangerous cross-link
in hypertension. Small artery damage includes functional (vasoconstriction, impaired …

Physical activity, including walking, has numerous health benefits in older adults, supported
by a plethora of observational and interventional studies. Walking decreases the risk or …

Age-related impairment of neurovascular coupling (NVC; or “functional hyperemia”)
compromises moment-to-moment adjustment of regional cerebral blood flow to increased …

Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …

Abstract Purpose of Review Precision Aging® is a novel concept that we have recently
employed to describe how the model of precision medicine can be used to understand and …

Age-related cerebrovascular defects contribute to vascular cognitive impairment and
dementia (VCID) as well as other forms of dementia. There has been great interest in …

Cerebral microvascular rarefaction, the reduction in number of functional or structural small
blood vessels in the brain, is thought to play an important role in the early stages of …

The present and future research efforts in cognitive neuroscience and psychophysiology rely
on the measurement, understanding, and interpretation of blood oxygenation level …