Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

The S100B protein: A multifaceted pathogenic factor more than a biomarker

F Michetti, ME Clementi, R Di Liddo, F Valeriani… - International Journal of …, 2023 - mdpi.com
S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

S100B protein as a therapeutic target in multiple sclerosis: The S100B inhibitor arundic acid protects from chronic experimental autoimmune encephalomyelitis

C Camponeschi, M De Carluccio, S Amadio… - International journal of …, 2021 - mdpi.com
S100B is an astrocytic protein behaving at high concentration as a damage-associated
molecular pattern molecule. A direct correlation between the increased amount of S100B …

Growing role of S100B protein as a putative therapeutic target for neurological-and nonneurological-disorders

F Michetti, G Di Sante, ME Clementi… - Neuroscience & …, 2021 - Elsevier
S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

[HTML][HTML] ONO-2506 can delay levodopa-induced dyskinesia in the early stage

Y Yuan, X Zhang, Y Wu, P Lian, X Cao, Y Xu - Neuroscience, 2023 - Elsevier
Background: Levodopa-induced dyskinesia (LID) is a common motor complication of
levodopa (L-DOPA) treatment for Parkinson's disease (PD). In recent years, the role of …

Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific …

APR Martini, LM Schlemmer… - Frontiers in …, 2024 - frontiersin.org
Background Chronic cerebral hypoperfusion (CCH) leads to memory and learning
impairments associated with degeneration and gliosis in the hippocampus. Treatment with …

Effects of acrobatic training on spatial memory and astrocytic scar in CA1 subfield of hippocampus after chronic cerebral hypoperfusion in male and female rats

APR Martini, E Hoeper, TA Pedroso… - Behavioural Brain …, 2022 - Elsevier
Chronic cerebral hypoperfusion leads to neuronal loss in the hippocampus and spatial
memory impairments. Physical exercise is known to prevent cognitive deficits in animal …

Therapeutic hypothermia for the treatment of neonatal hypoxia-ischemia: sex-dependent modulation of reactive astrogliosis

RB Fabres, RR Nunes, M de Medeiros de Mattos… - Metabolic Brain …, 2022 - Springer
Therapeutic hypothermia (TH) is the standard treatment for neonatal hypoxia-ischemia (HI)
with a time window limited up to 6 h post injury. However, influence of sexual dimorphism in …

Role and Therapeutic Potential of Non-coding RNAs in Astrocytes during Neonatal Brain Injury

Z Ye, T Yuan - 2023 - preprints.org
Perinatal brain injury is a major public health problem burdened with high morbidity,
mortality and severe neurological sequelae. Despite advances in neonatal life-saving …

Efeitos da administração intracerebroventricular de ácido arúndico sobre aspectos histológicos, bioquímicos e comportamentais no modelo experimental de …

JL Cordeiro - 2020 - lume.ufrgs.br
A hemorragia intracerebral (HIC) consiste no principal subtipo de acidente vascular cerebral
(AVC) hemorrágico, sendo responsável por altas taxas de mortalidade e graves sequelas …