Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved
in inhibition of apoptosis and regulation of cell cycle. These functional attributes make …

Background Emerging evidence suggests a potential relationship between gut microbiota
and the host response to chemotherapeutic drugs including 5-fluorouracil (5-Fu) …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous
potential to provide improved cellular models of human disease. However, variable genetic …

Inhibitors of programmed cell death (apoptosis) aberrantly prolonging cell viability may
contribute to cancer1 by facilitating the insurgence of mutations and by promoting resistance …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Apoptosis is a physiological cell suicide program that is critical for the development and
maintenance of healthy tissues. Dysregulation of cell death pathways occur in cancer …

▪ Abstract Caspase activation plays a central role in the execution of apoptosis. The key
components of the biochemical pathways of caspase activation have been recently …

Defective or inefficient apoptosis is an acquired hallmark of cancer cells. Thus, a thorough
understanding of apoptotic signaling pathways and insights into apoptosis resistance …