Pancreatic adenocarcinoma (PAC) is associated with extremely poor prognosis and remains
a lethal malignancy. The main cure for PAC is surgical resection. Further treatment …

During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

Cancer vaccines are designed to promote tumor specific immune responses, particularly
cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines …

Recent clinical trials revealed the impressive efficacy of immunological checkpoint blockade
in different types of metastatic cancers. Such data underscore that immunotherapy is one of …

Simple Summary Hepatocellular carcinoma (HCC) is the most common liver malignancy
associated with poor prognosis. Treatment options are limited partially due to resistance to …

Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the
lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance …

Indoleamine 2, 3-dioxigenase 1 (IDO1) is the main enzyme that catalyzes the first, rate-
limiting step of the so-called “kynurenine pathway”, ie, the metabolic cascade that converts …

Many new therapies are currently being used to treat cancer. Among these new methods,
chemotherapy based on peptides has been of great interest due to the unique advantages …

Highlights•Immunopeptidomics analysis reveals the in vivo antigenic repertoire of
tumors.•Shared cancer antigens and private neo-epitopes are detected by …

It is now clear that human neoplasms form, progress, and respond to therapy in the context
of an intimate crosstalk with the host immune system. In particular, accumulating evidence …