Let fever do its job: the meaning of fever in the pandemic era

S Wrotek, EK LeGrand, A Dzialuk… - Evolution, medicine, and …, 2021 - academic.oup.com
Although fever is one of the main presenting symptoms of COVID-19 infection, little public
attention has been given to fever as an evolved defense. Fever, the regulated increase in …

New Insights into the Role of Glutathione in the Mechanism of Fever

S Wrotek, J Sobocińska, HM Kozłowski… - International journal of …, 2020 - mdpi.com
Glutathione is one of the most important and potent antioxidants. The development of
pharmacological compounds that can either increase or decrease glutathione …

The (p) ppGpp synthetase RSH mediates stationary-phase onset and antibiotic stress survival in Clostridioides difficile

A Pokhrel, A Poudel, KB Castro… - Journal of …, 2020 - Am Soc Microbiol
The human pathogen Clostridioides difficile is increasingly tolerant of multiple antibiotics
and causes infections with a high rate of recurrence, creating an urgent need for new …

Roles of cytokines in modulating Trypanosoma brucei rhodesiense infection outcomes in vervet monkeys

V Adung'a, C Jebet, T John, D Masiga, O John, M Field… - 2024 - researchsquare.com
Human African trypanosomiasis (HAT), caused by Trypanosoma brucei rhodesiense,
remains a threat in east and southern African regions. The disease is widely categorised as …

[HTML][HTML] Glucocorticoid effects on sheep peripheral blood mononuclear cell proliferation and cytokine production under in vitro hyperthermia

M Caroprese, MG Ciliberti, P De Palo, A Santillo… - Journal of dairy …, 2018 - Elsevier
The present experiment aimed at understanding the effects of cortisol levels on sheep
peripheral blood mononuclear cell (PBMC) proliferation and cytokine production during …

Unique features of magic spot metabolism in Clostridioides difficile

A Poudel, A Pokhrel, A Oludiran, EJ Coronado… - bioRxiv, 2021 - biorxiv.org
The 'magic spot'alarmones (pp) pGpp, previously implicated in Clostridioides difficile
antibiotic survival, are synthesized by CdRSH and CdRelQ. These enzymes are …

Evaluating the role of the stringent response mechanism in Clostridioides difficile survival and pathogenesis

A Pokhrel - 2021 - search.proquest.com
The human pathogen Clostridioides difficile causes infections with a high rate of recurrence,
creating an urgent need for new preventive and therapeutic strategies. The stringent …

Toward antitumor immunity and febrile infections: gamma/Delta (γδ) T cells hypothesis

W Kozak, T Jedrzejewski… - … Quarterly Review of …, 2018 - journals.uchicago.edu
Retrospective as well as prospective clinical studies indicate that episodes of high fever as a
typical reaction to an acute infection during the entire human life span are inversely related …

Relationships between animal temperament and systemic immune responses in beef cattle exposed to conditions associated with conventional management

AW Altman - 2018 - uknowledge.uky.edu
Measures of temperament have been shown to influence physiological responses. Exit
velocity (EV) has been identified as an objective, robust measure of temperament that can …

Mechanisms of Stress Survival in Gram Positive Bacterial Pathogens

A Poudel - 2021 - search.proquest.com
Anaerobic Gram-positive bacteria are not a well-characterized group but include many
human pathogens that are resilient against stresses caused by the human immune system …