Molecular tension probes for imaging forces at the cell surface
Conspectus Mechanical forces are essential for a variety of biological processes ranging
from transcription and translation to cell adhesion, migration, and differentiation. Through the …
from transcription and translation to cell adhesion, migration, and differentiation. Through the …
DNA nanotechnology as an emerging tool to study mechanotransduction in living systems
The ease of tailoring DNA nanostructures with sub‐nanometer precision has enabled new
and exciting in vivo applications in the areas of chemical sensing, imaging, and gene …
and exciting in vivo applications in the areas of chemical sensing, imaging, and gene …
DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity
T cells are triggered when the T-cell receptor (TCR) encounters its antigenic ligand, the
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …
The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation
T cells defend against cancer and viral infections by rapidly scanning the surface of target
cells seeking specific peptide antigens. This key process in adaptive immunity is sparked …
cells seeking specific peptide antigens. This key process in adaptive immunity is sparked …
Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation
Y Zhang, Y Qiu, AT Blanchard… - Proceedings of the …, 2018 - National Acad Sciences
Platelet aggregation at the site of vascular injury is essential in clotting. During this process,
platelets are bridged by soluble fibrinogen that binds surface integrin receptors. One mystery …
platelets are bridged by soluble fibrinogen that binds surface integrin receptors. One mystery …
Programmable multivalent DNA-origami tension probes for reporting cellular traction forces
Mechanical forces are central to most, if not all, biological processes, including cell
development, immune recognition, and metastasis. Because the cellular machinery …
development, immune recognition, and metastasis. Because the cellular machinery …
Mechanically triggered hybridization chain reaction
Cells transmit piconewton forces to receptors to mediate processes such as migration and
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …
immune recognition. A major challenge in quantifying such forces is the sparsity of cell …
RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes
Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …
ST6Gal-I–mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion
Heterogeneity within the glycocalyx influences cell adhesion mechanics and signaling.
However, the role of specific glycosylation subtypes in influencing cell mechanics via …
However, the role of specific glycosylation subtypes in influencing cell mechanics via …
Highly polyvalent DNA motors generate 100+ pN of force via autochemophoresis
AT Blanchard, AS Bazrafshan, J Yi, JT Eisman… - Nano …, 2019 - ACS Publications
Motor proteins such as myosin, kinesin, and dynein are essential to eukaryotic life and
power countless processes including muscle contraction, wound closure, cargo transport …
power countless processes including muscle contraction, wound closure, cargo transport …