Introduction The development of therapeutic antibodies targeting immune checkpoint
molecules (ICMs) that induce long-term remissions in cancer patients has revolutionized …

DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate
numerous cellular processes across all living organisms, creating intricate dynamic …

Co‐opting host cell protein synthesis is a hallmark of many virus infections. In response,
certain host defense proteins limit mRNA translation globally, albeit at the cost of the host …

Immune checkpoint blockade (ICB) therapies induce durable responses in approximately
15% of colorectal cancer (CRC) patients who exhibit microsatellite instability-high (MSI-H) or …

DNA sensor proteins play an important role in transducing DNA signals to induce immune
responses that initiate inflammation or clear pathogens. It has been previously shown that …

Background Glioblastoma multiforme (GBM) is a type of fast-growing brain glioma
associated with a very poor prognosis. This study aims to identify key genes whose …

Gliomas are aggressive brain tumors characterized by uncontrolled cell proliferation.
FAM64A, a cell cycle-related gene, has been found to promote cell proliferation in various …

Excessive proliferation, invasion, metastasis, and immune resistance in pancreatic cancer
(PC) makes it one of the most lethal malignant tumors. Recently, DDX60 was found to be …

Breast cancer (BC) cell secretome in the tumor microenvironment (TME) facilitates neo-
angiogenesis by promoting vascular endothelial cell (VEC) growth. Drugs that block BC cell …

Background Innate immunity is known to be implicated in the etiology of synovitis in
rheumatoid arthritis (RA). However, details of the molecular mechanisms have not been fully …