Phage therapy: An alternative treatment modality for MDR bacterial infections

N Pal, P Sharma, M Kumawat, S Singh… - Infectious …, 2024 - Taylor & Francis
The increasing global incidence of multidrug-resistant (MDR) bacterial infections threatens
public health and compromises various aspects of modern medicine. Recognising the …

Phage therapy: the pharmacology of antibacterial viruses

K Danis-Wlodarczyk, K Dąbrowska… - Current issues in …, 2021 - mdpi.com
Pharmacology can be differentiated into two key aspects, pharmacodynamics and
pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while …

Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo

EA Ashworth, RCT Wright, RK Shears… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …

Isolation of a bacteriophage targeting Pseudomonas aeruginosa and exhibits a promising in vivo efficacy

A Abdelghafar, A El-Ganiny, G Shaker, M Askoura - AMB Express, 2023 - Springer
Pseudomonas aeruginosa is an important pathogen that causes serious infections. Bacterial
biofilms are highly resistant and render bacterial treatment very difficult, therefore …

The applications of animal models in phage therapy: an update

F Mehmood Khan, P Manohar… - Human Vaccines & …, 2023 - Taylor & Francis
The rapid increase in antibiotic resistance presents a dire situation necessitating the need
for alternative therapeutic agents. Among the current alternative therapies, phage therapy …

Isolation, Characterization, and Genomic Analysis of Three Novel E. coli Bacteriophages That Effectively Infect E. coli O18

F Abdelrahman, N Rezk, MS Fayez, M Abdelmoteleb… - Microorganisms, 2022 - mdpi.com
Escherichia coli (E. coli) is one of the most common pathogenic bacteria worldwide. Avian
pathogenic E. coli (APEC) causes severe systemic disease in poultry (Colibacillosis), and …

Pseudomonas aeruginosa Bacteriophages and Their Clinical Applications

E Alipour-Khezri, M Skurnik, G Zarrini - Viruses, 2024 - mdpi.com
Antimicrobial resistance poses a serious risk to contemporary healthcare since it reduces
the number of bacterial illnesses that may be treated with antibiotics, particularly for patients …

[HTML][HTML] Therapeutic bacteriophages for Gram-negative bacterial infections in animals and humans

P Zagaliotis, J Michalik-Provasek, JJ Gill… - Pathogens and …, 2022 - ncbi.nlm.nih.gov
Drug-resistant Gram-negative bacterial pathogens are an increasingly serious health threat
causing worldwide nosocomial infections with high morbidity and mortality. Of these, the …

Bacteriophage treatment: critical evaluation of its application on World Health Organization priority pathogens

RK Al-Ishaq, S Skariah, D Büsselberg - Viruses, 2020 - mdpi.com
Bacteriophages represent an effective, natural, and safe strategy against bacterial infections.
Multiple studies have assessed phage therapy's efficacy and safety as an alternative …

Animal models to translate phage therapy to human medicine

A Brix, M Cafora, M Aureli, A Pistocchi - International journal of molecular …, 2020 - mdpi.com
Phagotherapy, the use of bacteriophages to fight bacterial infections as an alternative to
antibiotic treatments, has become of increasing interest in the last years. This is mainly due …