Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Abstract Cardiomyocyte Na+ and Ca 2+ mishandling, upregulated Ca 2+/calmodulin-
dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …

The development of the foetal heart is driven by increased glucose uptake and activation of
mammalian target of rapamycin (mTOR) and hypoxia‐inducible factor‐1α (HIF‐1α), which …

Diabetic cardiomyopathy has been reported to increase the risk of fatal ventricular
arrhythmia. The beneficial effects of the selective sodium-glucose cotransporter-2 inhibitor …

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide,
highlighting the high socioeconomic impact. Current treatment strategies like compound …