For decades, mankind has dominated the battle against bacteria, yet the tide is slowly
turning. Our antibacterial strategies are becoming less effective, allowing bacteria to get the …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Antibiotics can induce mutations that cause antibiotic resistance. Yet, despite their
importance, mechanisms of antibiotic-promoted mutagenesis remain elusive. We report that …

Candida glabrata has thoroughly adapted to successfully colonize human mucosal
membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all …

Bacteria encounter a myriad of potentially growth-compromising conditions in nature and in
hosts of pathogenic bacteria. These 'stresses' typically elicit protective and/or adaptive …

The main causes of antibiotic resistance are the selection of naturally occurring resistant
variants and horizontal gene transfer processes. In recent years, the implications of antibiotic …

Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few
proteins acting on DNA, yet the identities and functions of all proteins required are unknown …

Genomic instability underlies many cancers and generates genetic variation that drives
cancer initiation, progression, and therapy resistance. In contrast with classical assumptions …

Homologous recombination-mediated genome engineering has been broadly applied in
prokaryotes with high efficiency and accuracy. However, this method is limited in realizing …

Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal
role in the equilibrium between genetic stability and diversity. HR is commonly considered to …