Evolution and emergence of Mycobacterium tuberculosis

M Orgeur, C Sous, J Madacki… - FEMS Microbiology …, 2024 - academic.oup.com
Tuberculosis (TB) remains one of the deadliest infectious diseases in human history,
prevailing even in the 21st century. The causative agents of TB are represented by a group …

Hybracter: enabling scalable, automated, complete and accurate bacterial genome assemblies

G Bouras, G Houtak, RR Wick… - Microbial …, 2024 - microbiologyresearch.org
Improvements in the accuracy and availability of long-read sequencing mean that complete
bacterial genomes are now routinely reconstructed using hybrid (ie short-and long-reads) …

Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host

PJ Gómez-González, AD Grabowska… - Frontiers in …, 2023 - frontiersin.org
Introduction Around 10% of the coding potential of Mycobacterium tuberculosis is constituted
by two poorly understood gene families, the pe and ppe loci, thought to be involved in host …

Expression, Purification, and Bioinformatic Prediction of Mycobacterium tuberculosis Rv0439c as a Potential NADP+-Retinol Dehydrogenase

W Tang, C Gui, T Zhang - Molecular Biotechnology, 2023 - Springer
Although the genome of Mycobacterium tuberculosis (Mtb) H37Rv, the causative agent of
tuberculosis, has been repeatedly annotated and updated, a range of proteins from this …

The chosen few: Mycobacterium tuberculosis isolates for IMPAc-TB

SE Larsen, HFM Abdelaal, CR Plumlee… - Frontiers in …, 2024 - frontiersin.org
The three programs that make up the Immune Mechanisms of Protection Against
Mycobacterium tuberculosis Centers (IMPAc-TB) had to prioritize and select strains to be …

High-throughput nanopore targeted sequencing for efficient drug resistance assay of Mycobacterium tuberculosis

C Tang, L Wu, M Li, J Dai, Y Shi, Q Wang, F Xu… - Frontiers in …, 2024 - frontiersin.org
Drug-resistant tuberculosis (TB), especially multidrug-resistant tuberculosis (MDR-TB) and
extensively drug-resistant tuberculosis (XDR-TB), is one of the urgent clinical problems and …

Naked-Eye LAMP Assay of M. tuberculosis in Sputum by In Situ Au Nanoprobe Identification: For the In Vitro Diagnostics of Tuberculosis

X Zhang, Y Tian, Y Shi, J Liu, C Zhao… - ACS Infectious …, 2024 - ACS Publications
In spite of the development of diagnostic tests for Mycobacterium tuberculosis (M.
tuberculosis), the etiological agent of tuberculosis, there has remained a gap between the …

Pan-lineage Mycobacterium tuberculosis reference genome for enhanced molecular diagnosis

K Bahk, J Sung, M Seki, K Kim, J Kim, H Choi… - DNA …, 2024 - academic.oup.com
In Mycobacterium tuberculosis (MTB) control, whole genome sequencing-based molecular
drug susceptibility testing (molDST-WGS) has emerged as a pivotal tool. However, the …

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

A Osugi, A Tamaru, T Yoshiyama, T Iwamoto… - Microbiology …, 2024 - Am Soc Microbiol
Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of
latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious …

[HTML][HTML] Improved Isolation Optimizes Downstream Application of Extracellular Vesicles Derived from Mycobacterium tuberculosis

W Wang, Y Hou, J Zhang, Z Sun, H Sun - Microorganisms, 2024 - mdpi.com
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, secretes extracellular
vesicles (EVs), which may play an important role in mediating interactions between bacteria …