Circulating tumor cells: biology and clinical significance

D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal Transduction and Targeted Therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

[HTML][HTML] Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis

J Wu, S Hu, L Zhang, J Xin, C Sun, L Wang, K Ding… - Theranostics, 2020 - ncbi.nlm.nih.gov
Liquid biopsy is a convenient, fast, non-invasive and reproducible sampling method that can
dynamically reflect the changes in tumor gene expression profile, and provide a robust basis …

EMT-associated heterogeneity in circulating tumor cells: sticky friends on the road to metastasis

A Genna, AM Vanwynsberghe, AV Villard, C Pottier… - Cancers, 2020 - mdpi.com
Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Multifunctional cellular targeting, molecular delivery, and imaging by integrated mesoporous-silica with optical nanocrescent antenna: MONA

Y Park, HJ Yoon, SE Lee, LP Lee - ACS nano, 2022 - ACS Publications
Multifunctional nanoprobes have attracted significant attention in a wide range of disciplines
such as nanomedicine, precision medicine, and cancer diagnosis and treatment. However …

[HTML][HTML] Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy

D Liu, Y Hong, Y Li, C Hu, TC Yip, WK Yu, Y Zhu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy
resistance. Therefore, a CSC-targeted therapy that disrupts the maintenance and survival of …

High clinical value of liquid biopsy to detect circulating tumor cells and tumor exosomes in pancreatic ductal adenocarcinoma patients eligible for up-front surgery

E Buscail, C Alix-Panabières, P Quincy, T Cauvin… - Cancers, 2019 - mdpi.com
Purpose: Expediting the diagnosis of pancreatic ductal adenocarcinoma (PDAC) would
benefit care management, especially for the start of treatments requiring histological …

The role of circulating tumor cells in the metastatic cascade: biology, technical challenges, and clinical relevance

H Dianat-Moghadam, M Azizi, Z Eslami-S… - Cancers, 2020 - mdpi.com
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …

Recent advances in microfluidic platform for physical and immunological detection and capture of circulating tumor cells

MP Bhat, V Thendral, UT Uthappa, KH Lee, M Kigga… - Biosensors, 2022 - mdpi.com
CTCs (circulating tumor cells) are well-known for their use in clinical trials for tumor
diagnosis. Capturing and isolating these CTCs from whole blood samples has enormous …

Early dissemination of circulating tumor cells: biological and clinical insights

F Chemi, S Mohan, T Guevara, A Clipson… - Frontiers in …, 2021 - frontiersin.org
Circulating tumor cells (CTCs) play a causal role in the development of metastasis, the major
cause of cancer-associated mortality worldwide. In the past decade, the development of …