The role of ROS in tumour development and progression

EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …

ROS production by mitochondria: function or dysfunction?

FR Palma, BN Gantner, MJ Sakiyama, C Kayzuka… - Oncogene, 2024 - nature.com
In eukaryotic cells, ATP generation is generally viewed as the primary function of
mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are …

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

Y Wang, R Branicky, A Noë, S Hekimi - Journal of Cell Biology, 2018 - rupress.org
Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

MA Incalza, R D'Oria, A Natalicchio, S Perrini… - Vascular …, 2018 - Elsevier
Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as
important second messengers within the cells; however, an imbalance between generation …

Reactive oxygen species and cancer paradox: to promote or to suppress?

S Galadari, A Rahman, S Pallichankandy… - Free Radical Biology …, 2017 - Elsevier
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Reactive oxygen species: Role in carcinogenesis, cancer cell signaling and tumor progression

FL Sarmiento-Salinas, A Perez-Gonzalez… - Life Sciences, 2021 - Elsevier
Cancer is one of the major causes of death in the world and its global burden is expected to
continue increasing. In several types of cancers, reactive oxygen species (ROS) have been …

[HTML][HTML] A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

DG Kirova, K Judasova, J Vorhauser, T Zerjatke… - Developmental cell, 2022 - cell.com
Reactive oxygen species (ROS) at the right concentration promote cell proliferation in cell
culture, stem cells, and model organisms. However, the mystery of how ROS signaling is …

[HTML][HTML] ROS function in redox signaling and oxidative stress

M Schieber, NS Chandel - Current biology, 2014 - cell.com
Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …

Mitochondrial reactive oxygen species and cancer

LB Sullivan, NS Chandel - Cancer & metabolism, 2014 - Springer
Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron
transport chain activity. While initial studies focused on the damaging effects of reactive …

Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants

B Poljsak, D Šuput, I Milisav - Oxidative medicine and cellular …, 2013 - Wiley Online Library
Free radical damage is linked to formation of many degenerative diseases, including cancer,
cardiovascular disease, cataracts, and aging. Excessive reactive oxygen species (ROS) …