The use of RNA-based treatments in the field of cancer immunotherapy
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
The role of Notch, Hedgehog, and Wnt signaling pathways in the resistance of tumors to anticancer therapies
V Kumar, M Vashishta, L Kong, X Wu, JJ Lu… - Frontiers in cell and …, 2021 - frontiersin.org
Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …
In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
Cancer recurrence after surgical resection remains a significant cause of treatment failure.
Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that …
Here, we have developed an in situ formed immunotherapeutic bioresponsive gel that …
Disharmonic inflammatory signatures in COVID-19: augmented neutrophils' but impaired monocytes' and dendritic cells' responsiveness
Z Parackova, I Zentsova, M Bloomfield, P Vrabcova… - Cells, 2020 - mdpi.com
COVID-19, caused by SARS-CoV-2 virus, emerged as a pandemic disease posing a severe
threat to global health. To date, sporadic studies have demonstrated that innate immune …
threat to global health. To date, sporadic studies have demonstrated that innate immune …
Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity
L Hou, C Tian, Y Yan, L Zhang, H Zhang, Z Zhang - ACS nano, 2020 - ACS Publications
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are essential
components of the innate immune sensors to cytosolic DNA and elicit type I interferon (IFN) …
components of the innate immune sensors to cytosolic DNA and elicit type I interferon (IFN) …
WNT/β-catenin signaling pathway regulating T cell-inflammation in the tumor microenvironment
Immunotherapy with checkpoint inhibitors has greatly prolonged the overall survival of
cancer patients in melanoma and many other cancer types. However, only a subset of …
cancer patients in melanoma and many other cancer types. However, only a subset of …
Nano codelivery of oxaliplatin and folinic acid achieves synergistic chemo-immunotherapy with 5-fluorouracil for colorectal cancer and liver metastasis
FOLFOX, the combinational strategy of folinic acid (FnA), 5-fluorouracil (5-Fu), and
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …
Nanoparticle-mediated remodeling of the tumor microenvironment to enhance immunotherapy
Nanoscience has long been lauded as a method through which tumor-associated barriers
could be overcome. As successful as cancer immunotherapy has been, limitations …
could be overcome. As successful as cancer immunotherapy has been, limitations …
WNT signaling in cancer immunosurveillance
Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …
progression, and resistance to conventional cancer therapy in a variety of preclinical and …
Strategies for nonviral nanoparticle‐based delivery of CRISPR/Cas9 therapeutics
CRISPR‐based genome editing technology has become an important potential therapeutic
tool for various diseases. A vital challenge is to reach a safe, efficient, and clinically suitable …
tool for various diseases. A vital challenge is to reach a safe, efficient, and clinically suitable …