The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …

Simple Summary Epigenetic mechanisms including methylation play an essential role in
regulating gene expression not only in cancer cells but also in immune cells. Although role …

Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

DNA methylation represents a fundamental epigenetic mark that is associated with
transcriptional repression during development, maintenance of homeostasis, and disease …

The study of metabolism provides important information for understanding the biological
basis of cancer cells and the defects of cancer treatment. Disorders of polyamine …

Tregs require Foxp3 expression and induction of a specific DNA hypomethylation signature
during development, after which Tregs persist as a self-renewing population that regulates …

The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence
suggest that severe COVID-19 is associated with durable scars to the epigenome …

The dynamic changes in the epigenome resulting from the intricate interactions of genetic
and environmental factors play crucial roles in individual growth and development …

Autoimmune diseases are characterized by increased reactivity of the immune system
towards self-antigens, causing tissue damage. Although their etiology remains largely …

Immune cells are pivotal in the reaction to injury, whereupon, under ideal conditions, repair
and resolution phases restore homeostasis following initial acute inflammation. Immune cell …