Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy

D D'Eliseo, F Velotti - Journal of clinical medicine, 2016 - mdpi.com
Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer

S Serini, E Piccioni, N Merendino, G Calviello - Apoptosis, 2009 - Springer
It has recently become clear the role played by alterations in apoptosis during the
development of several chronic diseases (ie inflammatory, neurodegenerative and …

Comparative toxicity of oleic acid and linoleic acid on Jurkat cells

MF Cury-Boaventura, C Pompéia, R Curi - Clinical nutrition, 2004 - Elsevier
Background: Lipid emulsions for parenteral nutrition commercially available are mainly
composed of long-chain triacylglycerol containing a high proportion of ω-6 polyunsaturated …

Essential fatty acids, lipid peroxidation and apoptosis

UN Das - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 1999 - Elsevier
Essential fatty acids (EFAs) and their metabolites, especially gamma-linolenic acid,
arachidonic acid, eicosapentaenoic acid and decosahexaenoic acid are known to induce …

Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis

TM Lima, CC Kanunfre, C Pompeia, R Verlengia… - Toxicology in vitro, 2002 - Elsevier
The fatty acids have an important role in the control of leukocyte metabolism and function.
Higher concentrations of certain fatty acids, particularly polyunsaturated fatty acids (PUFAs) …

DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis* s⃞

CH Jakobsen, GL Størvold, H Bremseth… - Journal of lipid …, 2008 - ASBMB
Polyunsaturated fatty acids (PUFAs) are normal constituents of the diet, but have properties
different from other fatty acids (eg, through generation of signaling molecules). N-3 PUFAs …

Arachidonic acid cytotoxicity: can arachidonic acid be a physiological mediator of cell death?

C Pompeia, T Lima, R Curi - … its modulation by active agents or …, 2003 - Wiley Online Library
Arachidonic acid is a polyunsaturated fatty acid that mediates inflammation and the
functioning of several organs and systems either directly or upon its conversion into …

Effect of fatty acids on leukocyte function

C Pompéia, LR Lopes, CK Miyasaka… - Brazilian Journal of …, 2000 - SciELO Brasil
Fatty acids have various effects on immune and inflammatory responses, acting as
intracellular and intercellular mediators. Polyunsaturated fatty acids (PUFAs) of the omega-3 …

An improved resazurin-based cytotoxicity assay for hepatic cells

MK McMillian, L Li, JB Parker, L Patel, Z Zhong… - Cell biology and …, 2002 - Springer
A simple resazurin-based cytotoxicity assay is presented for screening of cytotoxicity in
hepatocytes and liver cell lines. Human hepatoma (HepG2) cells in 96-well culture plates …

Fatty acids-induced lipotoxicity and inflammation

S Savary, D Trompier, P Andréoletti… - Current drug …, 2012 - ingentaconnect.com
Fatty acids are known to serve as energetic substrates, key components of membrane lipids,
and as substrates for the synthesis of signaling molecules and complex lipids. They are also …