The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

All cells are influenced by mechanical forces. In the brain, force-generating and load-
bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal …

After ten years of progress and innovation, optical coherence elastography (OCE) based on
the propagation of mechanical waves has become one of the major and the most studied …

Neurological disorders are one of the most important public health concerns in developed
countries. Established brain imaging techniques such as magnetic resonance imaging (MRI) …

Traumatic brain injury (TBI) is a significant public health problem, on pace to become the
third leading cause of death worldwide by 2020. Moreover, emerging evidence linking …

Abstract Changes in tissue composition and cellular architecture have been associated with
neurological disease, and these in turn can affect biomechanical properties. Natural …

White matter in the brain is structurally anisotropic, consisting largely of bundles of aligned,
myelin-sheathed axonal fibers. White matter is believed to be mechanically anisotropic as …

Magnetic resonance elastography (MRE) is an imaging technique for noninvasively and
quantitatively assessing tissue stiffness, akin to palpation. MRE is further able assess the …

Biological cells are well known to respond to a multitude of chemical signals. In the nervous
system, chemical signaling has been shown to be crucially involved in development, normal …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …