It is becoming increasingly apparent that translational control plays an important role in the
regulation of gene expression in eukaryotic cells. Most of the known physiological effects on …

Protein synthesis in both eukaryotic and prokaryotic cells is a complex process requiring a
large number of macromolecules: initiation factors, elongation factors, termination factors …

The late embryogenesis abundant (LEA) proteins are plant proteins that are synthesized at
the onset of desiccation in maturing seeds and in vegetative organs exposed to water deficit …

The scanning model of translation initiation is a coherent description of how eukaryotic
ribosomes reach the initiation codon after being recruited to the capped 5′ end of …

INTRODUCTION Ribosomes are universally conserved assemblies composed of ribosomal
RNA (rRNA) and proteins, where rRNA plays key structural and functional roles. Despite …

The process by which translation is initiated has long been considered similar in Bacteria
and Eukarya but accomplished by a different unrelated set of factors in the two cases. This …

Microdeletions of the Y chromosome long arm are the most common mutations in infertile
males, where they involve one or more “azoospermia factors”(AZFa, b, and c) …

Studies of the budding yeast Saccharomyces cerevisiae have greatly advanced our
understanding of the posttranscriptional steps of eukaryotic gene expression. Given the wide …

The translation initiation factor eIF1A is necessary for directing the 43S preinitiation complex
from the 5′ end of the mRNA to the initiation codon in a process termed scanning. We have …

The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of∼ 600 kDa
that binds to the 40 S ribosome and promotes the binding of methionyl-tRNA i and mRNA …