Due to the spread of antibiotic resistance, global attention is focused on its inhibition and the
expansion of effective medicinal compounds. The novel functional properties of peptides …

Investigating protein–protein interactions is crucial for understanding cellular biological
processes because proteins often function within molecular complexes rather than in …

Background: Peptides play crucial roles in diverse cellular functions and participate in many
biological processes by interacting with a variety of proteins, which have also been exploited …

Protein-protein interactions (PPIs) play a critical role in various biological processes.
Accurately estimating the binding affinity of PPIs is essential for understanding the …

Protein-protein interactions govern a wide range of biological activity. A proper estimation of
the protein-protein binding affinity is vital to design proteins with high specificity and binding …

ABSTRACT Introduction Protein-protein interactions (PPIs) have been often considered
undruggable targets although they are attractive for the discovery of new therapeutics. The …

Peptides are prevalent in biology, mediating as many as 40% of protein-protein interactions,
and involved in other cellular functions such as transport and signaling. Their ability to bind …

Therapeutic protein, represented by antibodies, is of increasing interest in human medicine.
However, clinical translation of therapeutic protein is still largely hindered by different …

Existing therapies for neurodegenerative diseases like Parkinson's and Alzheimer's address
only their symptoms and do not prevent disease onset. Common therapeutic agents, such as …

Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for
replication origin firing, and as such for faithful genetic inheritance. Our biochemical and …