[HTML][HTML] Self-assembling protein nanoparticles in the design of vaccines
For over 100 years, vaccines have been one of the most effective medical interventions for
reducing infectious disease, and are estimated to save millions of lives globally each year …
reducing infectious disease, and are estimated to save millions of lives globally each year …
Plasmodium genomics: an approach for learning about and ending human malaria
JA Garrido-Cardenas, L González-Cerón… - Parasitology …, 2019 - Springer
Malaria causes high levels of morbidity and mortality in human beings worldwide. According
to the World Health Organization (WHO), about half a million people die of this disease each …
to the World Health Organization (WHO), about half a million people die of this disease each …
Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised …
S Rts - Lancet, 2015 - thelancet.com
Background The efficacy and safety of the RTS, S/AS01 candidate malaria vaccine during
18 months of follow-up have been published previously. Herein, we report the final results …
18 months of follow-up have been published previously. Herein, we report the final results …
Novel protein-based pneumococcal vaccines: assessing the use of distinct protein fragments instead of full-length proteins as vaccine antigens
T Lagousi, P Basdeki, J Routsias, V Spoulou - Vaccines, 2019 - mdpi.com
Non-serotype-specific protein-based pneumococcal vaccines have received extensive
research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal …
research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal …
Structure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs
Identification of potential drug targets as well as development of novel antimalarial
chemotherapies with unique mode of actions due to drug resistance by Plasmodium …
chemotherapies with unique mode of actions due to drug resistance by Plasmodium …
Immune senescence and vaccines to prevent herpes zoster in older persons
MJ Levin - Current opinion in immunology, 2012 - Elsevier
Varicella-zoster virus (VZV) T-cell-mediated immunity (VZV-CMI) in older persons prevents
latent VZV in sensory neurons from reactivating to cause herpes zoster. VZV-CMI declines …
latent VZV in sensory neurons from reactivating to cause herpes zoster. VZV-CMI declines …
A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and …
Background Dengue is one of the fastest spreading vector-borne diseases, caused by four
antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible …
antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible …
Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant-derived malaria vaccine candidates
S Menzel, T Holland, A Boes, H Spiegel… - Frontiers in plant …, 2016 - frontiersin.org
Plants provide an advantageous expression platform for biopharmaceutical proteins
because of their low pathogen burden and potential for inexpensive, large-scale production …
because of their low pathogen burden and potential for inexpensive, large-scale production …
Development of new strategies for malaria chemoprophylaxis: from monoclonal antibodies to long-acting injectable drugs
JJ Moehrle - Tropical Medicine and Infectious Disease, 2022 - mdpi.com
Drug discovery for malaria has traditionally focused on orally available drugs that kill the
abundant, parasitic blood stage. Recently, there has also been an interest in injectable …
abundant, parasitic blood stage. Recently, there has also been an interest in injectable …
[HTML][HTML] Downstream processing of a plant-derived malaria transmission-blocking vaccine candidate
S Menzel, T Holland, A Boes, H Spiegel… - Protein Expression and …, 2018 - Elsevier
Plants as a platform for recombinant protein expression are now economically comparable
to well-established systems, such as microbes and mammalian cells, thanks to advantages …
to well-established systems, such as microbes and mammalian cells, thanks to advantages …