Molecular mechanisms and therapeutic strategies for levodopa-induced dyskinesia in Parkinson's disease: a perspective through preclinical and clinical evidence
R Bandopadhyay, N Mishra, R Rana, G Kaur… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second leading neurodegenerative disease that is
characterized by severe locomotor abnormalities. Levodopa (L-DOPA) treatment has been …
characterized by severe locomotor abnormalities. Levodopa (L-DOPA) treatment has been …
Simvastatin as a potential disease-modifying therapy for patients with Parkinson's disease: rationale for clinical trial, and current progress
CB Carroll, RKH Wyse - Journal of Parkinson's disease, 2017 - content.iospress.com
Many now believe the holy grail for the next stage of therapeutic advance surrounds the
development of disease-modifying approaches aimed at intercepting the year-on-year …
development of disease-modifying approaches aimed at intercepting the year-on-year …
The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease
LW Hung, VL Villemagne, L Cheng… - Journal of Experimental …, 2012 - rupress.org
Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia,
rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies …
rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies …
A 20-hydroxyecdysone-enriched fraction from Pfaffia glomerata (Spreng.) pedersen roots alleviates stress, anxiety, and depression in mice
RR Franco, L de Almeida Takata, K Chagas… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Pfaffia glomerata roots are widely used in Brazil to treat
various pathological conditions, particularly psychological disorders. 20-hydroxyecdysone, a …
various pathological conditions, particularly psychological disorders. 20-hydroxyecdysone, a …
Reprint of “Animal models of early-stage Parkinson's disease and acute dopamine deficiency to study compensatory neurodegenerative mechanisms”
Parkinson's disease is a common neurodegenerative disease characterized by a widely
variety of motor and non-motor symptoms. While the motor deficits are only visible following …
variety of motor and non-motor symptoms. While the motor deficits are only visible following …
Omega-3 deficiency and neurodegeneration in the substantia nigra: involvement of increased nitric oxide production and reduced BDNF expression
HD Cardoso, EF dos Santos Junior… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Our previous study demonstrated that essential fatty acid (EFA) dietary
restriction over two generations induced midbrain dopaminergic cell loss and oxidative …
restriction over two generations induced midbrain dopaminergic cell loss and oxidative …
Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats
FE Padovan-Neto, R Cavalcanti-Kiwiatkoviski… - …, 2015 - Elsevier
It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry.
The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance …
The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance …
Subthalamic nucleus deep brain stimulation on motor-symptoms of Parkinson's disease: focus on neurochemistry
Deep brain stimulation (DBS) has become a standard therapy for Parkinson's disease (PD)
and it is also currently under investigation for other neurological and psychiatric disorders …
and it is also currently under investigation for other neurological and psychiatric disorders …
[HTML][HTML] Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity
V Bashkatova - World Journal of Psychiatry, 2021 - ncbi.nlm.nih.gov
Dopaminergic neurotoxicity is characterized by damage and death of dopaminergic
neurons. Parkinson's disease (PD) is a neurodegenerative disorder that primarily involves …
neurons. Parkinson's disease (PD) is a neurodegenerative disorder that primarily involves …
7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease
Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular
messenger systems in the brain. Nitric Oxide (NO) contributes to inducing signaling …
messenger systems in the brain. Nitric Oxide (NO) contributes to inducing signaling …