Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was
heralded as a major breakthrough of the decade in stem cell research. The ability to …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely
used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 …

Cancer is believed to arise primarily through accumulation of genetic mutations. Although
induced pluripotent stem cell (iPSC) generation does not require changes in genomic …

Conversion of somatic cells to pluripotency by defined factors is a long and complex process
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …

Although genomes are defined by their sequence, the linear arrangement of nucleotides is
only their most basic feature. A fundamental property of genomes is their topological …

Heterochromatin is integral to cell identity maintenance by impeding the activation of genes
for alternate cell fates. Heterochromatic regions are associated with histone 3 lysine 9 …

Postmitotic neurons require persistently active controls to maintain terminal differentiation.
Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis …

Since Flemming described a nuclear substance in the nineteenth century and named it
“chromatin,” this substance has fascinated biologists. What is the structure of chromatin …