Heart rate variability

I Cygankiewicz, W Zareba - Handbook of clinical neurology, 2013 - Elsevier
Heart rate variability (HRV) provides indirect insight into autonomic nervous system tone,
and has a well-established role as a marker of cardiovascular risk. Recent decades brought …

Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention

CA Massey, LP Sowers, BJ Dlouhy… - Nature Reviews …, 2014 - nature.com
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients
with refractory epilepsy, with an estimated 35% lifetime risk in this patient population. There …

Sudden unexpected death in epilepsy

S Shorvon, T Tomson - The Lancet, 2011 - thelancet.com
Sudden unexpected death in epilepsy (SUDEP) refers to the sudden death of a seemingly
healthy individual with epilepsy, usually occurring during, or immediately after, a tonic-clonic …

A systematic review and meta‐analysis of heart rate variability in epilepsy and antiepileptic drugs

PA Lotufo, L Valiengo, IM Bensenor, AR Brunoni - Epilepsia, 2012 - Wiley Online Library
Purpose: Epilepsy is associated with near‐fatal and fatal arrhythmias, and sudden
unexpected death in epilepsy (SUDEP) is partly related to cardiac events. Dysfunction of the …

Sudden unexpected death in a mouse model of Dravet syndrome

F Kalume, RE Westenbroek, CS Cheah… - The Journal of …, 2013 - Am Soc Clin Investig
Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in
intractable epilepsies, but physiological mechanisms that lead to SUDEP are unknown …

RMSSD, a measure of vagus-mediated heart rate variability, is associated with risk factors for SUDEP: the SUDEP-7 Inventory

CM DeGiorgio, P Miller, S Meymandi, A Chin, J Epps… - Epilepsy & Behavior, 2010 - Elsevier
OBJECTIVE: The goal of this study was to determine if specific measures of heart rate
variability (HRV) are associated with the total score on a new seven-item inventory for …

Heart rate variability in epilepsy: a potential biomarker of sudden unexpected death in epilepsy risk

KA Myers, LE Bello‐Espinosa, JD Symonds… - …, 2018 - Wiley Online Library
Objective Sudden unexpected death in epilepsy (SUDEP) is a tragic and devastating event
for which the underlying pathophysiology remains poorly understood; this study investigated …

Severe peri-ictal respiratory dysfunction is common in Dravet syndrome

YJ Kim, E Bravo, CK Thirnbeck… - The Journal of …, 2018 - Am Soc Clin Investig
Dravet syndrome (DS) is a severe childhood-onset epilepsy commonly due to mutations of
the sodium channel gene SCN1A. Patients with DS have a high risk of sudden unexplained …

Sudden unexpected death in epilepsy: mechanisms, prevalence, and prevention

R Surges, JW Sander - Current opinion in neurology, 2012 - journals.lww.com
Novel clinical features may help to define better the individual risk of SUDEP. Potentially
therapeutic strategies including pharmacological modulation of respiratory arrest and …

Heart rate variability measurement in epilepsy: How can we move from research to clinical practice?

KA Myers, S Sivathamboo, P Perucca - Epilepsia, 2018 - Wiley Online Library
Our objective was to critically evaluate the literature surrounding heart rate variability (HRV)
in people with epilepsy and to make recommendations as to how future research could be …