Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …

Real-time PCR is the method of choice in many laboratories for diagnostic and food
applications. This technology merges the polymerase chain reaction chemistry with the use …

We report DNA-and RNA-like systems built from eight nucleotide “letters”(hence the name
“hachimoji”) that form four orthogonal pairs. These synthetic systems meet the structural …

Recent advancements in the creation of artificial extra base pairs (unnatural base pairs,
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Signal amplification is a key component of molecular detection. Enzyme-free signal
amplification is especially appealing for the development of low-cost, point-of-care …

How can molecules compute? In his early studies of reversible computation, Bennett
imagined an enzymatic Turing Machine which modified a hetero-polymer (such as DNA) to …

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is
widespread among potentially natural nucleic acid alternatives taken from RNA's close …

While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed
hydrolysis of the nucleosidic bond, their C-analogues are much more stable. Several C …