Mechanisms of action of the peptide toxins targeting human and rodent acid-sensing ion channels and relevance to their in vivo analgesic effects
Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …
largely expressed in the nervous system of rodents and humans. At least six isoforms …
[HTML][HTML] Insight into a multifunctional potassium channel Kv1. 3 and its novel implication in chronic kidney disease
Z Dragan, CA Pollock, C Huang - Life Sciences, 2024 - Elsevier
Chronic kidney disease (CKD), a global public health problem, causes substantial morbidity
and mortality worldwide. Innovative therapeutic strategies to mitigate the progression of CKD …
and mortality worldwide. Innovative therapeutic strategies to mitigate the progression of CKD …
Nicotinic Acetylcholine Receptors Are Novel Targets of APETx-like Toxins from the Sea Anemone Heteractis magnifica
RS Kalina, IE Kasheverov, SG Koshelev, OV Sintsova… - Toxins, 2022 - mdpi.com
The nicotinic acetylcholine receptors (nAChRs) are prototypical ligand-gated ion channels,
provide cholinergic signaling, and are modulated by various venom toxins and drugs in …
provide cholinergic signaling, and are modulated by various venom toxins and drugs in …
Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica
IN Gladkikh, AA Klimovich, RS Kalina… - Toxins, 2023 - mdpi.com
Acid-sensing ion channels (ASICs) have been known as sensors of a local pH change
within both physiological and pathological conditions. ASIC-targeting peptide toxins could …
within both physiological and pathological conditions. ASIC-targeting peptide toxins could …
Pharmacological Screening of Venoms from Five Brazilian Micrurus Species on Different Ion Channels
JM Kleiz-Ferreira, H Bernaerts… - International Journal of …, 2022 - mdpi.com
Coral snake venoms from the Micrurus genus are a natural library of components with
multiple targets, yet are poorly explored. In Brazil, 34 Micrurus species are currently …
multiple targets, yet are poorly explored. In Brazil, 34 Micrurus species are currently …
Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling
Background The identification of novel toxins from overlooked and taxonomically
exceptional species bears potential for various pharmacological applications. The remipede …
exceptional species bears potential for various pharmacological applications. The remipede …
Marine natural products
Covering: January to the end of December 2022This review covers the literature published
in 2022 for marine natural products (MNPs), with 645 citations (633 for the period January to …
in 2022 for marine natural products (MNPs), with 645 citations (633 for the period January to …
Diversity of biological activities of crude venom extracted from five species of South China Sea anemones
P He, M Li, J Fu, Y Liao, B Yi, B Gao - Frontiers in Marine Science, 2024 - frontiersin.org
Developing novel, efficient, and safe peptide drugs from sea anemones has aroused great
interest in countries around the world today. Sea anemones contain complex protein and …
interest in countries around the world today. Sea anemones contain complex protein and …
Anxiolytic Effect of Peptides from Sea Anemone Heteractis crispa, Modulators of TRPV1 and ASIC Channels
OV Sintsova, RS Kalina, IN Gladkikh… - Doklady Biochemistry …, 2022 - Springer
A number of studies confirmed the involvement of transient receptor potential vanilloid
(TRPV) and acid-sensing (ASIC) ion channels in the physiological processes associated …
(TRPV) and acid-sensing (ASIC) ion channels in the physiological processes associated …