Hereditary nonpolyposis colorectal cancer (HNPCC) dates to Warthin's description of family
G, which he began studying in 1895. Warthin's observations were not fully appreciated until …

BACKGROUND Hereditary nonpolyposis colorectal cancer (HNPCC) dates to Aldred
Warthin's description of Family G a century ago. The phenotype features an excess of early …

An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few
colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles …

Mutations in the human APC gene cause various familial colon cancer syndromes. The
Multiple intestinal neoplasia (Min) mouse provides an excellent model for familial colon …

Over the last decade, a subset of familial adenomatous polyposis (FAP) patients with a
milder course of disease termed attenuated familial adenomatous polyposis (AFAP) has …

Prostate cancer (PCa) is the most prevalent cancer with a high mortality rate. The early and
accurate detection of PCa can significantly reduce mortality and saves lives. Hence, the …

Germ-line mutations of the tumor suppressor APC are implicated in attenuated
adenomatous polyposis coli (AAPC), a variant of familial adenomatous polyposis (FAP) …

Mutations in the APC gene are responsible for various familial and sporadic colorectal
cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop …

Colorectal cancer is the third leading cause of cancer-related deaths in both men and
women in the United States and is estimated to have affected 148,000 people in 2002. The …

Background The use of commercially available tests for genes linked to familial cancer has
aroused concern about the impact of these tests on patients. Familial adenomatous …